ArticleThe Journal of antimicrobial chemotherapy2011
Antibiotic and antiseptic resistance genes are linked on a novel mobile genetic element: Tn6087.
Article in The Journal of antimicrobial chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Characteristics of the integration sites and module structures of the Tn916 and its family.Scientific reports · 2025Article
- Current insights into the effects of cationic biocides exposure onFrontiers in microbiology · 2024Review
- A Critical Review of AMR Risks Arising as a Consequence of Using Biocides and Certain Metals in Food Animal Production.Antibiotics (Basel, Switzerland) · 2023Review
- UnravelingMicrobiology spectrum · 2023Article
- Inverse PCR-based detection reveal novel mobile genetic elements and their associated genes in the human oral metagenome.BMC oral health · 2022Article
- Effects of Dietary Antimicrobial Growth Promoters on Performance Parameters and Abundance and Diversity of Broiler Chicken Gut Microbiome and Selection of Antibiotic Resistance Genes.Frontiers in microbiology · 2022Article
- Deciphering the genetic network and programmed regulation of antimicrobial resistance in bacterial pathogens.Frontiers in cellular and infection microbiology · 2022Review
- Crystal structure of 9-amino-acridinium chlorideActa crystallographica. Section E, Crystallographic communications · 2021Article
- Recovery of gut microbiota in mice exposed to tetracycline hydrochloride and their correlation with host metabolism.Ecotoxicology (London, England) · 2021Article
- The Effects of Natural Products and Environmental Conditions on Antimicrobial Resistance.Molecules (Basel, Switzerland) · 2021Review
- Prevalence, diversity and transferability of the TnJournal of oral microbiology · 2021Article
- Detection of a Novel, and Likely Ancestral, TnGenes · 2020Article
- Genomic instability of TnSMU2 contributes to Streptococcus mutans biofilm development and competence in a cidB mutant.MicrobiologyOpen · 2019Article
- Determination of copy number and circularization ratio of TnJournal of oral microbiology · 2019Article
- PCR-based detection of composite transposons and translocatable units from oral metagenomic DNA.FEMS microbiology letters · 2016Article
- The Resistome of Farmed Fish Feces Contributes to the Enrichment of Antibiotic Resistance Genes in Sediments below Baltic Sea Fish Farms.Frontiers in microbiology · 2016Article
- Metagenomic insights into tetracycline effects on microbial community and antibiotic resistance of mouse gut.Ecotoxicology (London, England) · 2015Article
- Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens.Antibiotics (Basel, Switzerland) · 2015Review
- Minocycline resistance in an oral Streptococcus infantis isolate is encoded by tet(S) on a novel small, low copy number plasmid.FEMS microbiology letters · 2014Article
- Effect of subinhibitory concentrations of four commonly used biocides on the conjugative transfer of Tn916 in Bacillus subtilis.The Journal of antimicrobial chemotherapy · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTn916-like elements are one of the most common types of integrative and conjugative element (ICE). In this study we aimed to determine whether novel accessory genes, i.e. genes whose products are not involved in mobility or regulation, were present on a Tn916-like element (Tn6087) isolated from Streptococcus oralis from the human oral cavity.
methodsA minocycline-resistant isolate was analysed using restriction fragment length polymorphism (RFLP) analysis on amplicons derived from Tn916 and DNA sequencing to determine whether there were genetic differences in Tn6087 compared with Tn916. Mutational analysis was used to determine whether the novel accessory gene found was responsible for an observed extra phenotype.
resultsA novel Tn916-like element, Tn6087, is described that encodes both antibiotic and antiseptic resistance. The antiseptic resistance protein is encoded by a novel small multidrug resistance gene, designated qrg, that was shown to encode resistance to cetyltrimethylammonium bromide (CTAB), also known as cetrimide bromide.
conclusionsThis is the first Tn916-like element described that confers both antibiotic and antiseptic resistance, suggesting that selection of either antibiotic or antiseptic resistance will also select for the other and further highlights the need for prudent use of both types of compound.
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