ArticleThe Journal of surgical research2012
Gene expression variations in microsatellite stable and unstable colon cancer cells.
Article in The Journal of surgical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
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- Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array.Cell death discovery · 2017Article
- Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability.Oncotarget · 2016Article
- Association between mismatch repair gene and irinotecan-based chemotherapy in metastatic colon cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Gene expression in colon cancer: A focus on tumor site and molecular phenotype.Genes, chromosomes & cancer · 2015Article
- Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x.PloS one · 2013Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMicrosatellite instability (MSI) is a marker of chemoresistance, but it is associated with improved survival compared with microsatellite-stable (MSS) colon cancers. We hypothesized that MSI tumors overexpress chemoresistance-associated genes and underexpress DNA damage/repair genes. We used ultra high-throughput sequencing (UHTS) to assess the expression of representative genes in MSI and MSS colon cancer cell lines.
methodsSolexa UHTS was used to examine gene expression in HCT116 (MSI) and HT29 (MSS) cells, and normal colonic mucosa (NCM). We compared expression of 40 genes involved in chemoresistance, DNA repair, DNA damage, and drug metabolism pathways.
resultsWe observed gene expression differences between MSI and MSS cell lines in 8 out of 40 genes involved in mismatch repair (MMR), DNA repair, drug metabolism, and chemoresistance. MMR gene expression was lower in MSI cells, which is consistent with the MSI phenotype, whereas DNA repair genes were highly expressed in these cells. Genes associated with chemoresistance and drug metabolism also had increased expression in MSI cells. No difference in expression of DNA damage genes was observed between MSI and MSS cell lines.
conclusionUsing UHTS gene expression analysis, we identified differential expression of genes between MSI and MSS cell lines which may account for resistance to chemotherapy in MSI tumors. UHTS expression analysis has the potential to identify genome-wide predictors of response or resistance to chemotherapy.
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