ArticleCell2011
Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons.
Article in Cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 131 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 1 synthesis or guideline pooled it, 232 citations in OpenAlex.
- The cellular model for Alzheimer's disease research: PC12 cells.Frontiers in molecular neuroscience · 2022Pooled it
- Exploring the Skin Brain Link: Biomarkers in the Skin with Implications for Aging Research and Alzheimer's Disease Diagnostics.International journal of molecular sciences · 2023Article
- Current Status and Challenges of Stem Cell Treatment for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Review
- Early Actions of Neurotransmitters During Cortex Development and Maturation of Reprogrammed Neurons.Frontiers in synaptic neuroscience · 2019Review
- Myt1l induced direct reprogramming of pericytes into cholinergic neurons.CNS neuroscience & therapeutics · 2018Article
- Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors.Journal of experimental & clinical cancer research : CR · 2018Article
- Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming.Cellular and molecular life sciences : CMLS · 2018Review
- An update on stem cell biology and engineering for brain development.Molecular psychiatry · 2017Review
- A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue.Nature communications · 2017Article
- Understanding Parkinson's Disease through the Use of Cell Reprogramming.Stem cell reviews and reports · 2017Review
- Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in Neurotrauma.Frontiers in molecular neuroscience · 2017Review
- Stem Cells in Neurotoxicology/Developmental Neurotoxicology: Current Scenario and Future Prospects.Molecular neurobiology · 2016Review
- Role of SATB2 in human pancreatic cancer: Implications in transformation and a promising biomarker.Oncotarget · 2016Article
- Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells.Molecular and cellular neurosciences · 2016Review
- Transplantation of human induced cerebellar granular-like cells improves motor functions in a novel mouse model of cerebellar ataxia.American journal of translational research · 2016Article
- Recent Progress in Cell Reprogramming Technology for Cell Transplantation Therapy.Neurologia medico-chirurgica · 2016Review
- The epigenetics of aging and neurodegeneration.Progress in neurobiology · 2015Review
- Comparative transcriptomic analysis of multiple cardiovascular fates from embryonic stem cells predicts novel regulators in human cardiogenesis.Scientific reports · 2015Article
- Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Molecular genetics and genomics : MGG · 2015Review
71 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2014-04-10Ethical Violations by Author · Falsification/Fabrication of Data · Falsification/Fabrication of Image ·
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Retracted
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Directed conversion of mature human cells, as from fibroblasts to neurons, is of potential clinical utility for neurological disease modeling as well as cell therapeutics. Here, we describe the efficient generation of human-induced neuronal (hiN) cells from adult skin fibroblasts of unaffected individuals and Alzheimer's patients, using virally transduced transcription regulators and extrinsic support factors. hiN cells from unaffected individuals display morphological, electrophysiological, and gene expression profiles that typify glutamatergic forebrain neurons and are competent to integrate functionally into the rodent CNS. hiN cells from familial Alzheimer disease (FAD) patients with presenilin-1 or -2 mutations exhibit altered processing and localization of amyloid precursor protein (APP) and increased production of Aβ, relative to the source patient fibroblasts or hiN cells from unaffected individuals. Together, our findings demonstrate directed conversion of human fibroblasts to a neuronal phenotype and reveal cell type-selective pathology in hiN cells derived from FAD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.