ArticleVeterinary research2011
Skin mucus of Cyprinus carpio inhibits cyprinid herpesvirus 3 binding to epidermal cells.
Article in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 131 citations in OpenAlex.
- Integrated Sensory and Immune Cell Organization in the Lip Skin of the Goldfish (Animals : an open access journal from MDPI · 2026Article
- Bacterial diversity in the jelly of shark Ampullae of Lorenzini: a holobiont perspective.PeerJ · 2026Article
- In vivo multiscale analyses of spring viremia of carp virus (SVCV) infection: From model organism to target species.PLoS pathogens · 2024Article
- Vitamin D Promotes Mucosal Barrier System of Fish Skin Infected withInternational journal of molecular sciences · 2023Article
- Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents.Marine drugs · 2023Review
- Virus-induced interference as a means for accelerating fitness-based selection of cyprinid herpesvirus 3 single-nucleotide variantsVirus evolution · 2023Article
- Quality of DNA extracted from freshwater fish scales and mucus and its application in genetic diversity studies ofBiology methods & protocols · 2023Article
- Development of an attenuated vaccine against Koi Herpesvirus Disease (KHVD) suitable for oral administration and immersion.NPJ vaccines · 2022Article
- Article
- Don't Let It Get Under Your Skin! - Vaccination Protects the Skin Barrier of Common Carp From Disruption Caused by Cyprinid Herpesvirus 3.Frontiers in immunology · 2022Article
- Investigation of Cyprinid Herpesvirus 3 (CyHV-3) Disease Periods and Factors Influencing CyHV-3 Transmission in A Low Stocking Density Infection Trial.Animals : an open access journal from MDPI · 2021Article
- Effect of dietary isoleucine on skin mucus barrier and epithelial physical barrier functions of hybrid bagrid catfish Pelteobagrus vachelli × Leiocassis longirostris.Fish physiology and biochemistry · 2020Article
- Quantification of Defensive Proteins in Skin Mucus ofAnimals : an open access journal from MDPI · 2020Article
- Dissecting the factors shaping fish skin microbiomes in a heterogeneous inland water system.Microbiome · 2020Article
- Article
- Specific Evolution and Gene Family Expansion of Complement 3 and Regulatory Factor H in Fish.Frontiers in immunology · 2020Article
- Sea anemone and clownfish microbiota diversity and variation during the initial steps of symbiosis.Scientific reports · 2019Article
- Scrutinizing the triad of Vibrio tapetis, the skin barrier and pigmentation as determining factors in the development of skin ulcerations in wild common dab (Limanda limanda).Veterinary research · 2019Article
- Characterization of the skin mucus in the common octopus Octopus vulgaris (Cuvier) reared paralarvae.European journal of histochemistry : EJH · 2017Article
- Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Koi herpes virus disease (KHV).EFSA journal. European Food Safety Authority · 2017Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyprinid herpesvirus 3 (CyHV-3) is the aetiological agent of a mortal and highly contagious disease in common and koi carp. The skin is the major portal of entry of CyHV-3 in carp after immersion in water containing the virus. In the present study, we used in vivo bioluminescence imaging to investigate the effect of skin mucus removal and skin epidermis lesion on CyHV-3 entry. Physical treatments inducing removal of the mucus up to complete erosion of the epidermis were applied on a defined area of carp skin just before inoculation by immersion in infectious water. CyHV-3 entry in carp was drastically enhanced on the area of the skin where the mucus was removed with or without associated epidermal lesion. To investigate whether skin mucus inhibits CyHV-3 binding to epidermal cells, tail fins with an intact mucus layer or without mucus were inoculated ex vivo. While electron microscopy examination revealed numerous viral particles bound on the fins inoculated after mucus removal, no particle could be detected after infection of mucus-covered fins. Finally, anti-CyHV-3 neutralising activity of mucus extract was tested in vitro. Incubation of CyHV-3 with mucus extract reduced its infectivity in a dose dependent manner. The present study demonstrates that skin mucus removal and epidermal lesions enhance CyHV-3 entry in carp. It highlights the role of fish skin mucus as an innate immune protection against viral epidermal entry.
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