ArticleDigestive diseases and sciences2012
Increase of colonic mast cells in obstructed defecation and their relationship with enteric glia.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms.Scientific reports · 2018Trial
- Indian consensus on chronic constipation in adults: A joint position statement of the Indian Motility and Functional Diseases Association and the Indian Society of Gastroenterology.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018Article
- Enteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases.Inflammatory bowel diseases · 2016Review
- Gastrointestinal motility disorders in inflammatory bowel diseases.World journal of gastroenterology · 2014Review
- The association between prucalopride efficacy and constipation type.Techniques in coloproctology · 2013Article
- The role of colonic mast cells and myenteric plexitis in patients with diverticular disease.International journal of colorectal disease · 2013Article
- Mast cells in intestinal motility disorders: please also look beyond IBS….Digestive diseases and sciences · 2012Article
- Mast cells and intestinal motility disorders (mastocytic enteritis/colitis).Digestive diseases and sciences · 2012Article
- Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility.Drug target insights · 2012Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMast cells are involved in visceral hypersensitivity and motor activity of the gastrointestinal tract. However, there is almost no information concerning mast cells in constipated patients.
aimsThe purpose of this study was to investigate mast cells distribution in all colonic layers in controls and severely constipated patients with obstructed defecation.
methodsFull-thickness specimens from colons of patients undergoing surgery for obstructed defecation due to refractoriness to other therapeutic interventions (n = 11), compared to controls, were obtained and the number of mast cells (evaluated by specific monoclonal antibodies) were counted in the whole viscus and in the various colonic segments (cecum, ascending, transverse, descending, and sigmoid).
resultsCompared to controls, constipated patients had significantly higher numbers of mast cells, both as an overall number and in single colonic segments. This increase was especially evident in the mucosa and submucosa. Mast cells were homogeneously represented in the various segment of the large bowel, in both controls and patients. Degranulated mast cells were found to be close to enteric glial cells and glial filaments.
conclusionsColonic mast cells are increased in obstructed defecation patients. This might represent a vicariating mechanism to the impaired colonic propulsive activity of these patients.
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