ArticleInternational journal of medical sciences2011
A comparison of immuncapture agglutination and ELISA methods in serological diagnosis of brucellosis.
Article in International journal of medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 35 citations in OpenAlex.
- IgM and IgG Epitope Mapping of the Porin Outer Membrane Protein-2a fromInternational journal of molecular sciences · 2026Article
- Development of a dual fluorescent microsphere-based lateral flow immunoassays for simultaneous detection ofFrontiers in veterinary science · 2026Article
- Two Years, Many Clues: Diagnostic Journey and Treatment of Chronic Neurobrucellosis in an Elderly Woman.Cureus · 2025Article
- An ultra-sensitive and point-of-care time-resolved fluorescence immunochromatographic platform for trace-level brucellosis antibody rapid on-site detection.Journal of nanobiotechnology · 2025Article
- Unraveling brucellosis: advances in pathogenesis, diagnostic strategies, therapeutic innovations, and public health perspectives.Frontiers in medicine · 2025Review
- Evaluating the efficacy of serological testing of clinical specimens collected from patients with suspected brucellosis.PLoS neglected tropical diseases · 2023Article
- A Label-Based Polymer Nanoparticles Biosensor Combined with Loop-Mediated Isothermal Amplification for Rapid, Sensitive, and Highly Specific Identification ofFrontiers in bioengineering and biotechnology · 2021Review
- Clinical Interpretation of Detection of IgM Anti-Polish journal of microbiology · 2019Article
- Review of brucellosis in Nepal.International journal of veterinary science and medicine · 2016Review
- Comparison of a New and Rapid Method: Brucella Coombs Gel Test With Other Diagnostic Tests.Journal of clinical laboratory analysis · 2016Article
- Review of Brucellosis in Nepal.Epidemiology and health · 2016Review
- Rocket and Two Dimensional Immunoelectrophoresis in Diagnosis of Caprine Brucellosis.Iranian journal of public health · 2015Article
- Genetic and Non-Genetic Inheritance of Natural Antibodies Binding Keyhole Limpet Hemocyanin in a Purebred Layer Chicken Line.PloS one · 2015Article
- Detection of IgM antibrucella antibody in the absence of IgGs: a challenge for the clinical interpretation of brucella serology.PLoS neglected tropical diseases · 2014Article
- Characterization of the immunogenicity and pathogenicity of malate dehydrogenase in Brucella abortus.World journal of microbiology & biotechnology · 2014Article
- Evaluation of ELISA and Brucellacapt tests for diagnosis of human Brucellosis.Iranian journal of microbiology · 2013Article
- Brucellosis in Nepal - A Potential Threat to Public Health Professionals.Current health sciences journalArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent serological tests are used in serologic diagnosis of brucellosis. The most widely used of these are Standard Tube Agglutination and Coombs anti-brucella tests. Whereas ELISA Ig M and Ig G tests have been in use for a long time, immuncapture agglutination test has been recently introduced and used in serological diagnosis. The aim of this study was to compare diagnostic values of ELISA Ig M and Ig G and immuncapture agglutination tests with Coombs anti-brucella test.
methodsSera from 200 patients with presumptive diagnosis of brucellosis were included into the study. Coombs anti-brucella test, ELISA Ig M and Ig G tests and Immuncapture test were investigated in these sera. Then, sensitivity, specificity, negative predictive and positive predictive values were calculated.
resultsSensitivity, specificity, negative predictive and positive predictive values were found to be 90.6%, 76.3%, 94.2%, and 65.9% respectively for the Immuncapture test, whereas they were found to be 73.7%, 58.9%, 84.2%, and 42.8% for Ig G and 72.2%, 67.8%, 85.2%, and 48.7% for Ig M. The Immuncapture test was found to be compatible with ELISA Ig M and Ig G tests but it was statistically incompatible with Coombs anti-brucella test.
conclusionsImmuncapture agglutination test yields similar results to those of Coombs anti-brucella test. This test is a useful test by virtue of the fact that it determines blocking antibodies in the diagnosis and follow-up of brucellosis.
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