ArticlePharmaceuticals (Basel, Switzerland)2009
Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies.
Article in Pharmaceuticals (Basel, Switzerland), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
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Who cites it
27 citing papers in PubMed.
- Impaired Autophagic Flux in Glucose-Deprived Cells: An Outcome of Lysosomal Acidification Failure Exacerbated by Mitophagy Dysfunction.Molecules and cells · 2023Review
- AMPK-induced mitochondrial biogenesis decelerates retinal pigment epithelial cell degeneration under nutrient starvation.BMB reports · 2023Article
- Impact of blood factors on endothelial cell metabolism and function in two diverse heart failure models.PloS one · 2023Article
- Emerging Promise of Therapeutic Approaches Targeting Mitochondria in Neurodegenerative Disorders.Current neuropharmacology · 2023Review
- Novel biallelic variants in NRROS associated with a lethal microgliopathy, brain calcifications, and neurodegeneration.Neurogenetics · 2022Article
- MCT2 overexpression promotes recovery of cognitive function by increasing mitochondrial biogenesis in a rat model of stroke.Animal cells and systems · 2021Article
- Detection of mitochondria-pertinent components in exosomes.Mitochondrion · 2020Article
- High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways.Biomolecules · 2020Article
- Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities.British journal of pharmacology · 2019Review
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- Nesfatin-1 protects dopaminergic neurons against MPPScientific reports · 2017Article
- Mitochondria, Cybrids, Aging, and Alzheimer's Disease.Progress in molecular biology and translational science · 2017Review
- Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration.Frontiers in immunology · 2017Review
- Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease.Current topics in medicinal chemistry · 2016Review
- Targeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunities.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Neuroprotective effects of Psoralea corylifolia Linn seed extracts on mitochondrial dysfunction induced by 3-nitropropionic acid.BMC complementary and alternative medicine · 2014Article
- The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives.Biochimica et biophysica acta · 2014Review
- Bioenergetic medicine.British journal of pharmacology · 2014Review
- Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus.Vascular medicine (London, England) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Neurodegenerative diseases are a common late-life scourge for which disease-modifying treatments are sorely needed. Mitochondrial perturbation is commonly observed in these diseases, so pursuing treatment development strategies that target mitochondria or processes affected by mitochondria seems reasonable. This review discusses the rationale underlying past and current efforts to treat neurodegenerative diseases using mitochondrial medicine, and tries to predict how future efforts might proceed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.