ArticleCell death & disease2011
Reactive oxygen species initiate luminal but not basal cell death in cultured human mammary alveolar structures: a potential regulator of involution.
Article in Cell death & disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Breast milk stem cells integrate into cellular remodeling and functional differentiation in the ischemic brain.Scientific reports · 2025Article
- Equine Colostrum-Derived Mesenchymal Stromal Cells: A Potential Resource for Veterinary Regenerative Medicine.Veterinary sciences · 2025Article
- Mesenchymal stem cells and their secretome modulate stress and enhance lipogenesis in bovine mammary epithelial cells.Stem cell research & therapy · 2025Article
- Entourage effect for phenolic compounds on production and metabolism of mammary epithelial cells.Heliyon · 2022Article
- Pistacia lentiscus extract enhances mammary epithelial cells' productivity by modulating their oxidative status.Scientific reports · 2020Article
- Investigation on the suitability of milk-derived primary bovine mammary epithelial cells grown on permeable membrane supports as an in vitro model for lactation.In vitro cellular & developmental biology. Animal · 2020Article
- Stem cells in human breast milk.Human cell · 2019Review
- Mammary Stem Cells in Domestic Animals: The Role of ROS.Antioxidants (Basel, Switzerland) · 2018Review
- A genetic variant in SLC30A2 causes breast dysfunction during lactation by inducing ER stress, oxidative stress and epithelial barrier defects.Scientific reports · 2018Article
- Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.American journal of physiology. Endocrinology and metabolism · 2017Article
- Protection of Bovine Mammary Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Cell Damage by Resveratrol.Oxidative medicine and cellular longevity · 2016Article
- Gene expression in breastmilk cells is associated with maternal and infant characteristics.Scientific reports · 2015Article
- At the dawn of a new discovery: the potential of breast milk stem cells.Advances in nutrition (Bethesda, Md.) · 2014Review
- Senescence and aging: the critical roles of p53.Oncogene · 2013Review
- Breastmilk is a novel source of stem cells with multilineage differentiation potential.Stem cells (Dayton, Ohio) · 2012Article
- Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.Cell death & disease · 2012Article
- Cancer metabolism: current perspectives and future directions.Cell death & disease · 2012Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-lactational involution of the mammary gland is initiated within days of weaning. Clearing of cells occurs by apoptosis of the milk-secreting luminal cells in the alveoli and through stromal tissue remodeling to return the gland almost completely to its pre-pregnant state. The pathways that specifically target involution of the luminal cells in the alveoli but not the basal and ductal cells are poorly understood. In this study we show in cultured human mammary alveolar structures that the involution process is initiated by fresh media withdrawal, and is characterized by cellular oxidative stress, expression of activated macrophage marker CD68 and finally complete clearing of the luminal but not basal epithelial layer. This process can be simulated by ectopic addition of reactive oxygen species (ROS) in cultures without media withdrawal. Cells isolated from post-involution alveoli were enriched for the CD49f(+) mammary stem cell (MaSC) phenotype and were able to reproduce a complete alveolar structure in subcultures without any significant loss in viability. We propose that the ROS produced by accumulated milk breakdown post-weaning may be the mechanism underlying the selective involution of secretory alveolar luminal cells, and that our culture model represents an useful means to investigate this and other mechanisms further.
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Registered trials
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