ArticleKidney international2011
Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice.
Article in Kidney international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Targeting the Disease Response With NlpD and LytM for Effective Nonantibiotic Treatment of Urinary Tract Infections.The Journal of infectious diseases · 2026Article
- Essential role for the urothelial plaque in Gram-negative urinary tract infections.Scientific reports · 2026Article
- Unveiling the Therapeutic Potential of Dulaglutide in Mitigating Tacrolimus-Induced Nephrotoxicity Through Targeting the miR-22/HMGB-1/TLR4/MyD88/NF-κB Trajectory.Archiv der Pharmazie · 2025Article
- The immune mechanisms of the urinary tract against infections.Frontiers in cellular and infection microbiology · 2025Review
- Experimental Sepsis Models: Advantages and Limitations.The Eurasian journal of medicine · 2023Article
- Uropathogen and host responses in pyelonephritis.Nature reviews. Nephrology · 2023Review
- Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence.iScience · 2022Article
- Adiponectin alleviated renal cell apoptosis and inflammation via inactivation of JAK2/STAT3 signal pathway in an acute pyelonephritis mouse model.Annals of translational medicine · 2021Article
- Empagliflozin Inhibits IL-1β-Mediated Inflammatory Response in Human Proximal Tubular Cells.International journal of molecular sciences · 2021Article
- Proteomic and bioinformatic profiling of neutrophils in CLL reveals functional defects that predispose to bacterial infections.Blood advances · 2021Article
- A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis.PLoS pathogens · 2021Article
- The pathogenesis and management of renal scarring in children with vesicoureteric reflux and pyelonephritis.Pediatric nephrology (Berlin, Germany) · 2020Review
- Androgen exposure potentiates formation of intratubular communities and renal abscesses by Escherichia coli.Kidney international · 2018Article
- Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis.Disease models & mechanisms · 2017Article
- Inflammation drives renal scarring in experimental pyelonephritis.American journal of physiology. Renal physiology · 2017Article
- Current Murine Models of Sepsis.Surgical infections · 2016Review
- Androgens Enhance Male Urinary Tract Infection Severity in a New Model.Journal of the American Society of Nephrology : JASN · 2016Article
- Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages.Pathogens (Basel, Switzerland) · 2016Article
- Subversion of Host Innate Immunity by Uropathogenic Escherichia coli.Pathogens (Basel, Switzerland) · 2016Review
- CXCL5 drives neutrophil recruitment in TH17-mediated GN.Journal of the American Society of Nephrology : JASN · 2015Article
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6 authors.
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Abstract
The CXCR1 receptor and chemokine CXCL8 (IL-8) support neutrophil-dependent clearance of uropathogenic Escherichia coli from the urinary tract. CXCR1 is reduced in children prone to pyelonephritis, and heterozygous hCXCR1 polymorphisms are more common in this patient group than in healthy individuals, strongly suggesting a disease association. Since murine CXCR2 (mCXCR2) is functionally similar to human CXCR1, we determined effects of gene heterozygosity on the susceptibility to urinary tract infection by infecting heterozygous (mCxcr2(+/-)) mice with uropathogenic Escherichia coli. Clearance of infection and tissue damage were assessed as a function of innate immunity in comparison to that in knockout (mCxcr2(-/-)) and wild-type (mCxcr2(+/+)) mice. Acute sepsis-associated mortality was increased and bacterial clearance drastically impaired in heterozygous compared to wild-type mice. Chemokine and neutrophil responses were delayed along with evidence of neutrophil retention and unresolved kidney inflammation 1 month after infection. This was accompanied by epithelial proliferation and subepithelial fibrosis. The heterozygous phenotype was intermediate, between knockout and wild-type mice, but specific immune cell infiltrates that accompany chronic infection in knockout mice were not found. Hence, the known heterozygous CXCR1 polymorphisms may predispose patients to acute pyelonephritis and urosepsis.
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