ReviewCell cycle (Georgetown, Tex.)2011
Cilia and cell cycle re-entry: more than a coincidence.
Review in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Analysis from the perspective of cilia: the protective effect of PARP inhibitors on visual function during light-induced damage.International ophthalmology · 2020Pooled it
- Primary cilium as a sensory organelle and metabolic hub in health and diseases.Journal of biomedical science · 2026Review
- Multifaceted role of primary cilia and ciliary proteins: A potential nexus for hedgehog signaling and prostate cancer.Biochimica et biophysica acta. Molecular basis of disease · 2026Review
- Centriole Duplication, Maturation, and Transformation During Mammalian Spermatogenesis.Advances in experimental medicine and biology · 2026Review
- NIMA-related kinase family at the nexus of skeletal development and congenital arthrogryposis: coordinated regulation of cell cycle and ciliary dynamics.Frontiers in genetics · 2026Review
- Hedgehog pathway, cell cycle, and primary cilium.Cell death discovery · 2025Review
- Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis.Molecular neurodegeneration · 2025Article
- Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia.Fluids and barriers of the CNS · 2025Article
- Identification and bioinformatics analysis of cilia-associated gene families inFrontiers in microbiology · 2025Article
- SMPD4-mediated sphingolipid metabolism regulates brain and primary cilia development.Development (Cambridge, England) · 2024Article
- High water intake induces primary cilium elongation in renal tubular cells.Kidney research and clinical practice · 2024Article
- Polyploidy Promotes Hypertranscription, Apoptosis Resistance, and Ciliogenesis in Cancer Cells and Mesenchymal Stem Cells of Various Origins: Comparative Transcriptome In Silico Study.International journal of molecular sciences · 2024Article
- A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit.eLife · 2024Article
- Emerging principles of primary cilia dynamics in controlling tissue organization and function.The EMBO journal · 2023Review
- Article
- Shortening of primary cilia length is associated with urine concentration in the kidneys.Kidney research and clinical practice · 2023Article
- An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis.Nature communications · 2023Article
- Immunohistochemical identification of epithelial cell types in the isthmus of bovine oviduct: Comparison with the ampulla.The Journal of reproduction and development · 2023Article
- Brain microvascular endothelial cells possess a second cilium that arises from the daughter centriole.Frontiers in molecular biosciences · 2023Article
- Patterns of Ciliation and Ciliary Signaling in Cancer.Reviews of physiology, biochemistry and pharmacology · 2023Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
With the exception of the final stages of spermatogenesis in butterfly and some unicellular ciliates and flagellates, ciliated cells undergo cell division without cilia. This reciprocal relationship between cilia formation and cell division has prompted investigators to propose that ciliogenesis and cell cycle progression are mutually exclusive processes. Early work in fibroblasts showed that deciliation occurs in two waves, as cells depart from quiescence. The first wave of deciliation occurs before entry into S, while the second wave occurs between S and mitosis. Since then, it has remained a mystery whether and how (de)ciliation is coupled to the cell cycle and further, whether ciliation can affect cell cycle progression. Several recent publications provide evidence for a causative role of ciliary resorption in influencing the duration of the G1 phase of the cell cycle impacting on several developmental processes, including left-right patterning, kidney, skeletal and brain development. This body of work argues for the existence of a molecular crosstalk between ciliary factors and regulators of the cell cycle. Here, we review the evidence connecting primary cilia and the cell cycle and evaluate the idea that the primary cilium may function as a physical checkpoint in cell cycle re-entry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.