ReviewPrion
Transmission of prions within the gut and towards the central nervous system.
Review in Prion. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals?Molecules (Basel, Switzerland) · 2022Review
- The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson's Disease.Life (Basel, Switzerland) · 2021Review
- Nutraceuticals and Enteric Glial Cells.Molecules (Basel, Switzerland) · 2021Review
- Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS.Frontiers in neuroscience · 2021Review
- The receptor for advanced glycation endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting common ground for novel amyloidosis therapies.Protein science : a publication of the Protein Society · 2018Review
- The Gut Microbiome Feelings of the Brain: A Perspective for Non-Microbiologists.Microorganisms · 2017Review
- The Autophagoproteasome a Novel Cell Clearing Organelle in Baseline and Stimulated Conditions.Frontiers in neuroanatomy · 2016Article
- Alpha-synuclein transmission and mitochondrial toxicity in primary human foetal enteric neurons in vitro.Neurotoxicity research · 2014Article
- Prion-like mechanisms in epileptogenesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- The prion hypothesis in Parkinson's disease: Braak to the future.Acta neuropathologica communications · 2013Review
- Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders.Cell and tissue research · 2013Review
- Histochemical approaches to assess cell-to-cell transmission of misfolded proteins in neurodegenerative diseases.European journal of histochemistry : EJH · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prion protein is a glycoprotein characterized by a folded α-helical structure that, under pathological conditions, misfolds and aggregates into its infectious isoform as β-sheet rich amyloidic deposits. The accumulation of the abnormal protein is responsible for a group of progressive and fatal disorders characterized by vacuolation, gliosis, and spongiform degeneration. Prion disorders are characterized by a triple aetiology: familial, sporadic or acquired, although most cases are sporadic. The mechanisms underlying prion neurotoxicity remain controversial, while novel findings lead to hypothesize intriguing pathways responsible for prion spreading. The present review aims to examine the involvement of the gastrointestinal tract and hypothesizes the potential mechanisms underlying cell-to-cell transmission of the prion protein. In particular, a special emphasis is posed on the mechanisms of prion transmission within the gut and towards the central nervous system. The glycation of prion protein to form advanced glycation end-products (AGE) interacting with specific receptors placed on neighboring cells (RAGE) represents the key hypothesis to be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.