ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
High-sweat Na+ in cystic fibrosis and healthy individuals does not diminish thirst during exercise in the heat.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Thermophysiological and perceptual responses to exercise heat stress in people with cystic fibrosis on Elexacaftor/Tezacaftor/Ivacaftor.Experimental physiology · 2026Article
- Associations of personal temperature exposure in the preceding days with vital signs, biochemical, and hydration parameters in cystic fibrosis.Scientific reports · 2026Article
- Perspectives on enhancing human performance in the heat: Is the solution to simply "just add water"?Sports medicine and health science · 2025Review
- Remote analysis and management of sweat biomarkers using a wearable microfluidic sticker in adult cystic fibrosis patients.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs.Scientific reports · 2023Article
- Permanent tattooing has no impact on local sweat rate, sweat sodium concentration and skin temperature or prediction of whole-body sweat sodium concentration during moderate-intensity cycling in a warm environment.European journal of applied physiology · 2020Article
- Ad libitum water consumption prevents exercise-associated hyponatremia and protects against dehydration in soldiers performing a 40-km route-march.Military Medical Research · 2019Observational
- Considering exercise-associated hyponatraemia as a continuum.BMJ case reports · 2018Article
- Dehydration is how you define it: comparison of 318 blood and urine athlete spot checks.BMJ open sport & exercise medicine · 2018Article
- Interindividual variability in sweat electrolyte concentration in marathoners.Journal of the International Society of Sports Nutrition · 2016Article
- Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2014Article
- Cathelicidins: family of antimicrobial peptides. A review.Molecular biology reports · 2012Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Sweat Na(+) concentration ([Na(+)]) varies greatly among individuals and is particularly high in cystic fibrosis (CF). The purpose of this study was to determine whether excess sweat [Na(+)] differentially impacts thirst drive and other physiological responses during progressive dehydration via exercise in the heat. Healthy subjects with high-sweat [Na(+)] (SS) (91.0 ± 17.3 mmol/l), Controls with average sweat [Na(+)] (43.7 ± 9.9 mmol/l), and physically active CF patients with very high sweat [Na(+)] (132.6 ± 6.4 mmol/l) cycled in the heat without drinking until 3% dehydration. Serum osmolality increased less (P < 0.05) in CF (6.1 ± 4.3 mosmol/kgH(2)O) and SS (8.4 ± 3.0 mosmol/kgH(2)O) compared with Control (14.8 ± 3.5 mosmol/kgH(2)O). Relative change in plasma volume was greater (P < 0.05) in CF (-19.3 ± 4.5%) and SS (-18.8 ± 3.1%) compared with Control (-14.3 ± 2.3%). Thirst during exercise and changes in plasma levels of vasopressin, angiotensin II, and aldosterone relative to percent dehydration were not different among groups. However, ad libitum fluid replacement was 40% less, and serum NaCl concentration was lower for CF compared with SS and Control during recovery. Despite large variability in sweat electrolyte loss, thirst appears to be appropriately maintained during exercise in the heat as a linear function of dehydration, with relative contributions from hyperosmotic and hypovolemic stimuli dependent upon the magnitude of salt lost in sweat. CF exhibit lower ad libitum fluid restoration following dehydration, which may reflect physiological cues directed at preservation of salt balance over volume restoration.
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