ArticleThe American journal of tropical medicine and hygiene2011
Leptospirosis among hospitalized febrile patients in northern Tanzania.
Article in The American journal of tropical medicine and hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 6 of them syntheses that pooled it.
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The trial behind it
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Who cites it
59 citing papers in PubMed, 6 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Leptospirosis Seroprevalence in Humans and Livestock of East Africa: A Systematic Review and Meta-Analysis (2000-2024).Veterinary medicine and science · 2025Pooled it
- A systematic review and meta-analysis of the epidemiology of Leptospirosis in HIV uninfected and in people living with HIV from the Southern African Development Community.PLoS neglected tropical diseases · 2022Pooled it
- A systematic review and meta-analysis of the aetiological agents of non-malarial febrile illnesses in Africa.PLoS neglected tropical diseases · 2022Pooled it
- Epidemiology of leptospirosis in Tanzania: A review of the current status, serogroup diversity and reservoirs.PLoS neglected tropical diseases · 2021Pooled it
- Epidemiology of Leptospirosis in Africa: A Systematic Review of a Neglected Zoonosis and a Paradigm for 'One Health' in Africa.PLoS neglected tropical diseases · 2015Pooled it
- Global Morbidity and Mortality of Leptospirosis: A Systematic Review.PLoS neglected tropical diseases · 2015Pooled it
- Leptospirosis Incidence at Four Sites in Sub-Saharan Africa and South East Asia: An International Multi-Site Hybrid Surveillance Study.Open forum infectious diseases · 2026Article
- Leptospirosis Prevalence and Risk Factors Among Patients Presenting With Fever to 4 Healthcare Sites in Sub-Saharan Africa and South East Asia: An International Multisite Observational and Nested Case-Control Study.The Journal of infectious diseases · 2026Observational
- Leptospirosis.Nature reviews. Disease primers · 2025Review
- TaqMan Array Card real-time polymerase chain reaction panel to detect pathogens in whole blood of febrile inpatients in northern Tanzania, 2016-2019.Tropical medicine & international health : TM & IH · 2025Article
- Detection and Determinants ofPublic health challenges · 2025Article
- Molecular detection and typing of pathogenicEpidemiology and infection · 2025Article
- Leptospira seroprevalence and associated risk factors among slaughterhouse workers in Western Bahr El Ghazal State, South Sudan.PLoS neglected tropical diseases · 2024Article
- Metagenomic Detection of Bacterial Zoonotic Pathogens among Febrile Patients, Tanzania, 2007-2009Emerging infectious diseases · 2024Article
- Article
- Prevalence and risk factors for human leptospirosis at a hospital serving a pastoralist community, Endulen, Tanzania.PLoS neglected tropical diseases · 2023Article
- Prevalence of anti-leptospiral IgM and detection of pathogenic Leptospira species DNA in neonates presenting with clinical sepsis in Southwestern Uganda.European journal of medical research · 2022Article
- Seroprevalence, distribution, and risk factors for human leptospirosis in the United States Virgin Islands.PLoS neglected tropical diseases · 2022Article
- Seropositivity ofTropical medicine and infectious disease · 2022Article
- Leptospirosis outbreak in Tanzania: An alarming situation.Annals of medicine and surgery (2012) · 2022Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
We enrolled consecutive febrile admissions to two hospitals in Moshi, Tanzania. Confirmed leptospirosis was defined as a ≥ 4-fold increase in microscopic agglutination test (MAT) titer; probable leptospirosis as reciprocal MAT titer ≥ 800; and exposure to pathogenic leptospires as titer ≥ 100. Among 870 patients enrolled in the study, 453 (52.1%) had paired sera available, and 40 (8.8%) of these met the definition for confirmed leptospirosis. Of 832 patients with ≥ 1 serum sample available, 30 (3.6%) had probable leptospirosis and an additional 277 (33.3%) had evidence of exposure to pathogenic leptospires. Among those with leptospirosis the most common clinical diagnoses were malaria in 31 (44.3%) and pneumonia in 18 (25.7%). Leptospirosis was associated with living in a rural area (odds ratio [OR] 3.4, P < 0.001). Among those with confirmed leptospirosis, the predominant reactive serogroups were Mini and Australis. Leptospirosis is a major yet underdiagnosed cause of febrile illness in northern Tanzania, where it appears to be endemic.
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Registered trials
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