ArticleThe American journal of tropical medicine and hygiene2011
Cryptosporidium meleagridis: infectivity in healthy adult volunteers.
Article in The American journal of tropical medicine and hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- The Gut-Wrenching Effects of Cryptosporidiosis and Giardiasis in Children.Microorganisms · 2023Review
- An Update on ZoonoticAnimals : an open access journal from MDPI · 2021Review
- Megasphaera in the Stool Microbiota Is Negatively Associated With Diarrheal Cryptosporidiosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Observational
- Successful experimental infant baboon model for childhood cryptosporidiosis studies.Parasites & vectors · 2021Article
- Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition.PLoS pathogens · 2021Article
- Opportunities and Challenges in Developing aACS infectious diseases · 2021Article
- Review
- Prevalence and molecular characterization ofOne health (Amsterdam, Netherlands) · 2020Article
- Evolutionary genomics of anthroponosis in Cryptosporidium.Nature microbiology · 2019Article
- Past and future trends of Cryptosporidium in vitro research.Experimental parasitology · 2019Review
- Molecular investigation of Cryptosporidium in farmed chickens in Hubei Province, China, identifies 'zoonotic' subtypes of C. meleagridis.Parasites & vectors · 2018Article
- Multicenter Evaluation of BD Max Enteric Parasite Real-Time PCR Assay for Detection of Giardia duodenalis, Cryptosporidium hominis, Cryptosporidium parvum, and Entamoeba histolytica.Journal of clinical microbiology · 2016Article
- Public health significance of zoonoticInternational journal for parasitology. Parasites and wildlife · 2016Review
- Application of salivary antibody immunoassays for the detection of incident infections with Norwalk virus in a group of volunteers.Journal of immunological methods · 2015Article
- Cryptosporidium muris: infectivity and illness in healthy adult volunteers.The American journal of tropical medicine and hygiene · 2015Article
- Molecular identification of Cryptosporidium spp. in seagulls, pigeons, dogs, and cats in Thailand.Parasite (Paris, France) · 2014Article
- Looking for Cryptosporidium: the application of advances in detection and diagnosis.Trends in parasitology · 2013Review
- Human cryptosporidiosis caused by Cryptosporidium tyzzeri and C. parvum isolates presumably transmitted from wild mice.Journal of clinical microbiology · 2013Article
- Burden of disease from cryptosporidiosis.Current opinion in infectious diseases · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Most Cryptosporidium infections in humans are caused by C. parvum or C. hominis. However, genotyping techniques have identified infections caused by unusual Cryptosporidium species. Cryptosporidium meleagridis has been identified in ≤ 1% of persons with diarrhea, although prevalence is higher in developing nations. We examined the infectivity of C. meleagridis in healthy adults. Five volunteers were challenged with 10(5) C. meleagridis oocysts and monitored six weeks for fecal oocysts and clinical manifestations. Four volunteers had diarrhea; three had detectable fecal oocysts; and one infected volunteer remained asymptomatic. Fecal DNA from two volunteers was amplified by using a polymerase chain reaction specific for the Cryptosporidium small subunit ribosomal RNA gene. Nucleotide sequence of these amplicons was diagnostic for C. meleagridis. All infections were self-limited; oocysts were cleared within ≤ 12 days of challenge. These studies establish that healthy adults can be infected and become ill from ingestion of C. meleagridis oocysts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.