Evidence map›Paper›PMID 21813807›Full record

Trial reportThe American journal of clinical nutrition2011

Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1.

Gladys Block, Nishat Shaikh, Christopher D Jensen, Vitaly Volberg, Nina Holland

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00079963 (Gender, Obesity, C-Reactive Protein, and Oxidative Stress), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00079963 nacompletednot on this map

Gender, Obesity, C-Reactive Protein, and Oxidative Stress

TypeinterventionalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran2004 to 2008Enrolled396ConditionsCardiovascular DiseaseArmsVitamin C, Vitamin E, Placebo
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Genetic Polymorphisms ofJournal of pharmacy & bioallied sciences
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gladys BlockSchool of Public Health, University of California at Berkeley, 94720-7360, USA. gblock@berkeley.edu
Nishat Shaikh
Christopher D Jensen
Vitaly Volberg
Nina Holland
University of California, Berkeley · US

Funding

VIROLOGY AND CHRONIC INFECTIONP30ES001896 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, MARTYN T · 1985 to 2003
$4.7M
Obesity, Inflammation, and Oxidative StressR01DK062378 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI BLOCK, GLADYS · 2004 to 2011
$4.2M
Oxidative Damage in Smokers and Passive SmokersR03CA096412 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BLOCK, GLADYS · 2002 to 2003
$150k
NCI NIH HHS R03 CA096412NIDDK NIH HHS 5R01DK062378-04NIDDK NIH HHS 5R01DK062378-06NIEHS NIH HHS P30 ES001896
6 · The paper itself

Abstract

backgroundGlutathione S-transferases (GSTs) detoxify environmental chemicals and are involved in oxidative stress pathways. Deletion polymorphisms affect enzyme activities and have been associated with risk of disease.

objectiveThe objective was to clarify whether biomarkers of oxidation, antioxidation, inflammation, and nutritional factors differ by GST genotype in healthy adults.

designSubjects (n = 383) consisted of nonsmokers and nonusers of antiinflammatory drugs and antioxidant vitamin supplements. Deletion polymorphisms of GSTM1 and GSTT1 were genotyped. F(2)-isoprostanes, malondialdehyde, C-reactive protein, serum vitamin C, carotenoids, tocopherols, and other nutritional factors were assessed.

resultsThe concentration of serum vitamin C was higher in persons with the inactive GSTM1-0 genotype (P = 0.006). This relation was unchanged after adjustment for age, sex, BMI, or dietary vitamin C. F(2)-isoprostanes and malondialdehyde were lower in the GSTM1-0 and GSTT1-0 groups, respectively, but significance was lost after control for serum vitamin C. The dual deletion, GSTM1-0/GSTT1-0 (n = 37), was associated with higher serum iron and total and LDL-cholesterol concentrations (all P < 0.01) and lower malondialdehyde concentrations, which persisted after adjustment for age, sex, BMI, and serum vitamin C. Carotenoids and α- and γ-tocopherols were not associated with either genotype.

conclusionsOxidative stress and inflammation biomarkers differ by GST genotype, but serum vitamin C appears to be the most consistent factor. Examination of other relevant genes may be needed to understand the concentration and function of ascorbic acid in the GST enzyme system. This trial is registered at clinicaltrials.gov as NCT00079963.

Indexed as

Polymorphism, GeneticAdultAscorbic AcidBiomarkersCholesterolCholesterol, LDLF2-IsoprostanesFemaleGenotypeGlutathione TransferaseHumansIronMaleMalondialdehydeMetabolic Detoxication, Phase IIMiddle AgedAscorbic AcidBiomarkersCholesterolCholesterol, LDLF2-Isoprostanesglutathione S-transferase T1Glutathione TransferaseIronMalondialdehyde

Identifiers

PMID21813807
PMCPMC3155929
OpenAlexW2126752776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.