ArticleDevelopment (Cambridge, England)2011
The roles of maternal Vangl2 and aPKC in Xenopus oocyte and embryo patterning.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Cellular and molecular mechanisms underlying planar cell polarity pathway contributions to cancer malignancy.Seminars in cell & developmental biology · 2018Review
- Cell polarity and planar cell polarity (PCP) in spermatogenesis.Seminars in cell & developmental biology · 2018Review
- CLAMP/Spef1 regulates planar cell polarity signaling and asymmetric microtubule accumulation in theThe Journal of cell biology · 2018Article
- Vangl2 regulates spermatid planar cell polarity through microtubule (MT)-based cytoskeleton in the rat testis.Cell death & disease · 2018Article
- Rare Deleterious PARD3 Variants in the aPKC-Binding Region are Implicated in the Pathogenesis of Human Cranial Neural Tube Defects Via Disrupting Apical Tight Junction Formation.Human mutation · 2017Article
- Planar cell polarity (PCP) proteins and spermatogenesis.Seminars in cell & developmental biology · 2016Review
- Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development.Seminars in cell & developmental biology · 2015Review
- Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation.Development (Cambridge, England) · 2015Article
- Article
- The Xenopus Maternal-to-Zygotic Transition from the Perspective of the Germline.Current topics in developmental biology · 2015Review
- Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer.Endocrine-related cancer · 2014Review
- Retromer promotes immune quiescence by suppressing Spätzle-Toll pathway in Drosophila.Journal of cellular physiology · 2014Article
- It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry.Communicative & integrative biology · 2013Article
- Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5.PloS one · 2013Article
- The planar cell polarity protein VANGL2 coordinates remodeling of the extracellular matrix.Communicative & integrative biology · 2012Article
- VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration.Journal of cell science · 2012Article
- Polarity proteins are required for left-right axis orientation and twin-twin instruction.Genesis (New York, N.Y. : 2000) · 2012Article
- Cell polarity as a regulator of cancer cell behavior plasticity.Annual review of cell and developmental biology · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Xenopus oocyte contains components of both the planar cell polarity and apical-basal polarity pathways, but their roles are not known. Here, we examine the distribution, interactions and functions of the maternal planar cell polarity core protein Vangl2 and the apical-basal complex component aPKC. We show that Vangl2 is distributed in animally enriched islands in the subcortical cytoplasm in full-grown oocytes, where it interacts with a post-Golgi v-SNARE protein, VAMP1, and acetylated microtubules. We find that Vangl2 is required for the stability of VAMP1 as well as for the maintenance of the stable microtubule architecture of the oocyte. We show that Vangl2 interacts with atypical PKC, and that both the acetylated microtubule cytoskeleton and the Vangl2-VAMP1 distribution are dependent on the presence of aPKC. We also demonstrate that aPKC and Vangl2 are required for the cell membrane asymmetry that is established during oocyte maturation, and for the asymmetrical distribution of maternal transcripts for the germ layer and dorsal/ventral determinants VegT and Wnt11. This study demonstrates the interaction and interdependence of Vangl2, VAMP1, aPKC and the stable microtubule cytoskeleton in the oocyte, shows that maternal Vangl2 and aPKC are required for specific oocyte asymmetries and vertebrate embryonic patterning, and points to the usefulness of the oocyte as a model to study the polarity problem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.