Trial reportFertility and sterility2011
Bisphenol A exposure reduces the estradiol response to gonadotropin stimulation during in vitro fertilization.
Trial report in Fertility and sterility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Assessment of ovarian dysfunction induced by environmental toxins: a systematic review.Frontiers in public health · 2025Pooled it
- Bisphenol A exposure and associations with obesity among adults: a critical review.Public health nutrition · 2015Pooled it
- Bisphenol-A and human oocyte maturation in vitro.Human reproduction (Oxford, England) · 2013Trial
- Effects of Bisphenols on the Assisted Reproductive Technology Outcomes Considering the Patient Clinical Parameters.Journal of the Endocrine Society · 2025Article
- The effects of endocrine disruptors on the female reproductive system.Turkish journal of medical sciences · 2025Review
- The impact of Bisphenol-A on human reproductive health.Toxicology reports · 2024Review
- Impact of Bisphenol A and its alternatives on oocyte health: a scoping review.Human reproduction update · 2024Article
- Toxicological Impact of Bisphenol A on Females' Reproductive System: Review Based on Experimental and Epidemiological Studies.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Fertility loss: negative effects of environmental toxicants on oogenesis.Frontiers in physiology · 2023Review
- Bisphenol-A and Female Fertility: An Update of Existing Epidemiological Studies.Journal of clinical medicine · 2022Review
- Article
- Female Reproductive Health and Exposure to Phthalates and Bisphenol A: A Cross Sectional Study.Toxics · 2021Article
- Effects of Bisphenol A Released From Composite Fillings on Reproductive Hormone Levels in Men.International dental journal · 2021Article
- Prenatal Exposure to Bisphenols and Phthalates and Postpartum Depression: The Role of Neurosteroid Hormone Disruption.The Journal of clinical endocrinology and metabolism · 2021Article
- The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality.Advances in experimental medicine and biology · 2021Article
- Effects of Environmental Endocrine-Disrupting Chemicals on Female Reproductive Health.Advances in experimental medicine and biology · 2021Article
- Environmental toxicant exposure and menstrual cycle length.Current opinion in endocrinology, diabetes, and obesity · 2020Review
- Bisphenol A: an emerging threat to female fertility.Reproductive biology and endocrinology : RB&E · 2020Review
- Bisphenol S Impaired Human Granulosa Cell Steroidogenesis in Vitro.International journal of molecular sciences · 2020Article
- Establishment and depletion of the ovarian reserve: physiology and impact of environmental chemicals.Cellular and molecular life sciences : CMLS · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveTo investigate associations between serum bisphenol A (BPA) concentrations and follicular response to exogenous ovary stimulation.
designFasting serum was prospectively collected on the day of oocyte retrieval and assessed for unconjugated BPA using high-performance liquid chromatography with Coularray detection. Multivariable linear regression and negative binomial regression were used to assess associations between concentrations of BPA and outcome measures. Models were adjusted for race/ethnicity, antral follicle count at baseline, and cigarette smoking.
settingA reproductive health center. PATIENT(S): Forty-four women undergoing IVF. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Peak E(2) level and the number of oocytes retrieved during IVF. RESULT(S): The median unconjugated serum BPA concentration is 2.53 ng/mL (range = 0.3-67.36 ng/mL). Bisphenol A is inversely associated with E(2) (β = -0.16; 95% confidence interval = -0.32, 0.01), as well as with E(2) normalized to the number of mature-sized follicles at the hCG trigger (β = -0.14; 95% confidence interval = -0.24, -0.03). No association is observed for BPA and the number of oocytes retrieved (adjusted risk ratio = 0.95; 95% confidence interval = 0.82, 1.10). CONCLUSION(S): Bisphenol A is associated with a reduced E(2) response during IVF. Although limited by the preliminary nature of this study, these results merit confirmation in a future comprehensive investigation.
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Registered trials
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