ArticleRetrovirology2011
Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor.
Article in Retrovirology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- Proviral location affects cognate peptide-induced virus production and immune recognition of HIV-1-infected T cell clones.The Journal of clinical investigation · 2023Article
- Ongoing HIV-1 evolution and reservoir reseeding in two elite controllers with genetically diverse peripheral proviral quasispecies.Memorias do Instituto Oswaldo Cruz · 2023Article
- High frequency of CD8 escape mutations in elite controllers as new obstacle for HIV cure.Virulence · 2022Article
- DeepTCR is a deep learning framework for revealing sequence concepts within T-cell repertoires.Nature communications · 2021Article
- Non-synonymous Substitutions in HIV-1 GAG Are Frequent in Epitopes Outside the Functionally Conserved Regions and Associated With Subtype Differences.Frontiers in microbiology · 2020Article
- A T Cell Receptor Sequencing-Based Assay Identifies Cross-Reactive Recall CD8Frontiers in immunology · 2020Article
- Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control.Retrovirology · 2018Article
- CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles.Journal of virology · 2016Article
- Multilayered HIV-1 gag-specific T-cell responses contribute to slow progression in HLA-A*30-B*13-C*06-positive patients.AIDS (London, England) · 2015Article
- Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections.Medical microbiology and immunology · 2015Review
- Sequence-specific alterations of epitope production by HIV protease inhibitors.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice.Journal of virology · 2014Article
- Levels of CD56+TIM-3- effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy.PloS one · 2014Article
- CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants.Retrovirology · 2013Article
- Article
- The implications of viral reservoirs on the elite control of HIV-1 infection.Cellular and molecular life sciences : CMLS · 2013Review
- Viral quasispecies evolution.Microbiology and molecular biology reviews : MMBR · 2012Review
- Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity.Journal of virology · 2012Article
- Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.Journal of virology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Elite suppressors or controllers (ES) are HIV-1 infected patients who maintain undetectable viral loads without treatment. While HLA-B*57-positive ES are usually infected with virus that is unmutated at CTL epitopes, a single, dominant variant containing CTL escape mutations is typically seen in plasma during chronic infection. We describe an ES who developed seven distinct and rare escape variants at an HLA-B*57-restricted Gag epitope over a five year period. Interestingly, he developed proliferative, de novo CTL responses that suppressed replication of each of these variants. These responses, in combination with low viral fitness of each variant, may contribute to sustained elite control in this ES.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.