ArticleRespiratory research2011
Low bone mineral density in men with chronic obstructive pulmonary disease.
Article in Respiratory research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Osteoporosis in COPD patients: Risk factors and pulmonary rehabilitation.The clinical respiratory journal · 2022Pooled it
- The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis.International journal of chronic obstructive pulmonary disease · 2016Pooled it
- Vitamin D deficiency is associated with the severity of COPD: a systematic review and meta-analysis.International journal of chronic obstructive pulmonary disease · 2015Pooled it
- Rational use of inhaled corticosteroids for the treatment of COPD.NPJ primary care respiratory medicine · 2023Review
- The regulation of RANKL by mechanical force.Journal of bone and mineral metabolism · 2021Review
- Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease.Frontiers in endocrinology · 2021Review
- Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement.International journal of chronic obstructive pulmonary disease · 2020Article
- Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study.BMC pulmonary medicine · 2019Article
- Predicting fracture risk in patients with chronic obstructive pulmonary disease: a UK-based population-based cohort study.BMJ open · 2019Article
- Association between airflow limitation severity and reduced bone mineral density in Japanese men.International journal of chronic obstructive pulmonary disease · 2019Article
- Relationship of annual change in bone mineral density with extent of emphysematous lesions and pulmonary function in patients with COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema.PloS one · 2018Article
- Oral contraceptive use and fracture risk-a retrospective study of 12,970 women in the UK.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Hospital admissions and mortality in patients with COPD exacerbations and vertebral body compression fractures.International journal of chronic obstructive pulmonary disease · 2017Article
- The Relationship of Bone Mineral Density in Men with Chronic Obstructive Pulmonary Disease Classified According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Combined Chronic Obstructive Pulmonary Disease (COPD) Assessment System.Internal medicine (Tokyo, Japan) · 2017Article
- Osteoporosis Associated with Chronic Obstructive Pulmonary Disease.Journal of bone metabolism · 2016Review
- Role of Osteoprotegerin and Receptor Activator of Nuclear Factor-κB Ligand in Bone Loss Related to Advanced Chronic Obstructive Pulmonary Disease.Chinese medical journal · 2016Article
- Usefulness of ceruloplasmin testing as a screening methodology for geriatric patients with osteoporosis.Journal of physical therapy science · 2016Article
- Benefits of Whole-Body Vibration, as a Component of the Pulmonary Rehabilitation, in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review with a Suitable Approach.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- COPD and osteoporosis: links, risks, and treatment challenges.International journal of chronic obstructive pulmonary disease · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis is common in patients with COPD but the likely multi-factorial causes contributing to this condition (e.g. sex, age, smoking, therapy) mask the potential contribution from elements related to COPD. In order to study osteoporosis and bone mineral density (BMD) related to COPD, we studied a well-defined group of patients and controls.
methodsBMD, forced expiratory volume in one second (FEV1), circulating bone biomarkers and biochemistry were determined in 30 clinically stable male ex-smokers with confirmed COPD and 15 age matched "ex-smoker" male controls. None of the patients were on inhaled corticosteroids or received more than one short course of steroids.
resultsMean (SD) FEV1% predicted of patients was 64(6)%, the majority having Global Initiative for Chronic Obstructive Lung Disease (GOLD) II airflow obstruction. There were 5/30 patients and 1/15 controls who were osteoporotic, while a further 17 patients and 5 controls were osteopenic. The BMD at the hip was lower in patients than controls, but not at the lumbar spine. Mean values of procollagen type 1 amino-terminal propeptide and osteocalcin, both markers of bone formation, and Type 1 collagen β C-telopeptide, a marker of bone resorption, were similar between patients and controls. However, all bone biomarkers were inversely related to hip BMD in patients (r = -0.51, r = -0.67, r = -0.57, p < 0.05) but did not relate to lumbar spine BMD. 25-OH Vitamin D was lower in patients.
conclusionsMen with COPD had a greater prevalence of osteoporosis and osteopenia than age matched male controls, with a marked difference in BMD at the hip. Bone biomarkers suggest increased bone turnover.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.