ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2011
Transforming growth factor beta expression by human vascular cells inhibits interferon gamma production and arterial media injury by alloreactive memory T cells.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Transforming growth factor (TGF)-β levels and unprovoked recurrent venous thromboembolism.Journal of thrombosis and thrombolysis · 2014Trial
- Cardiac allograft vasculopathy: current review and future research directions.Cardiovascular research · 2021Review
- Deficiency in CD4 T Cells Leads to Enhanced Postpartum Internal Carotid Artery Vasoconstriction in Mice: The Role of Nitric Oxide.Frontiers in physiology · 2021Article
- Pathogenesis of atherosclerosis in the tunica intima, media, and adventitia of coronary arteries: An updated review.Bosnian journal of basic medical sciences · 2020Review
- FGF signaling contributes to atherosclerosis by enhancing the inflammatory response in vascular smooth muscle cells.Molecular medicine reports · 2019Article
- Immune cells and vasa vasorum in the tunica media of atherosclerotic coronary arteries.Bosnian journal of basic medical sciences · 2018Article
- Humanized Mouse Models for Transplant Immunology.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016Review
- Interacting mechanisms in the pathogenesis of cardiac allograft vasculopathy.Arteriosclerosis, thrombosis, and vascular biology · 2014Review
- Age-dependent defective TGF-beta1 signaling in patients undergoing coronary artery bypass grafting.Journal of cardiothoracic surgery · 2014Article
- Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.The Journal of clinical investigation · 2014Article
- Human allograft rejection in humanized mice: a historical perspective.Cellular & molecular immunology · 2012Review
- The complex regulation of TGF-β in cardiovascular disease.Vascular health and risk management · 2012Review
- Participation of blood vessel cells in human adaptive immune responses.Trends in immunology · 2012Review
- Activation of human vascular cells decreases their expression of transforming growth factor-beta.Atherosclerosis · 2011Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Arteriosclerosis is characterized by the local activation of effector T cells leading to production of proinflammatory cytokines, such as IFN (interferon)-γ and IL-17, within the vessel wall. Conversely, the production of antiinflammatory cytokines, for example, TGF-β, by regulatory lymphocytes is known to inhibit both the differentiation of naïve T cells into effector T cells and the development of arteriosclerosis in murine models. We investigated the role of TGF-β on the alloreactivity of human effector memory T cells (Tem). Quiescent vascular cells, but not Tem, expressed TGF-β. Blockade of TGF-β activity in cocultures of CD4(+) Tem with allogeneic endothelial cells significantly increased IFN-γ, but not IL-17, secretion. Additionally, serologic neutralization of TGF-β in immunodeficient mouse hosts of human coronary artery grafts into which allogeneic human T cells were adoptively transferred resulted in heavier medial infiltration by Tem, greater loss of medial smooth muscle cells and increased IFN-γ production within the grafts without significantly reducing either intimal injury or IL-17 production. Protective effects of TGF-β may be limited by fewer TGF-β-expressing vascular cells within the intimal compartment, by a reduction in the expression of TGF-β by vascular cells in rejecting grafts, or possibly to less effective suppression of Tem than naïve T cells.
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