ReviewJournal of cellular and molecular medicine2012
Endoplasmic reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes.
Review in Journal of cellular and molecular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Farnesysltransferase Inhibitor Prevents Burn Injury-Induced Metabolome Changes in Muscle.Metabolites · 2022Article
- Role of stilbenes against insulin resistance: A review.Food science & nutrition · 2021Review
- Activation of ER stress signalling increases mortality after a major trauma.Journal of cellular and molecular medicine · 2020Article
- Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Increased proliferation of hepatic periportal ductal progenitor cells contributes to persistent hypermetabolism after trauma.Journal of cellular and molecular medicine · 2020Article
- Aggregated and Hyperstable Damage-Associated Molecular Patterns Are Released During ER Stress to Modulate Immune Function.Frontiers in cell and developmental biology · 2019Article
- Hepatic steatosis associated with decreased β-oxidation and mitochondrial function contributes to cell damage in obese mice after thermal injury.Cell death & disease · 2018Article
- The bioenergetics of inflammation: insights into obesity and type 2 diabetes.European journal of clinical nutrition · 2017Review
- Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring.Nutrition & metabolism · 2017Article
- Burned Adults Develop Profound Glucose Intolerance.Critical care medicine · 2016Article
- Alternative Mechanism for White Adipose Tissue Lipolysis after Thermal Injury.Molecular medicine (Cambridge, Mass.) · 2016Article
- Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury.Critical care medicine · 2014Article
- Fenofibrate does not affect burn-induced hepatic endoplasmic reticulum stress.The Journal of surgical research · 2013Article
- Endoplasmic Reticulum Stress and Related Pathological Processes.Journal of pharmacological & biomedical analysis · 2013Article
- Clinical review: Glucose control in severely burned patients - current best practice.Critical care (London, England) · 2013Review
- Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease.Oxidative medicine and cellular longevity · 2013Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Type 2 diabetes, a rapidly growing disease of modern aetiology, has a profound impact on morbidity and mortality. Explosions in the understanding of the underlying cellular mechanisms which lead to type 2 diabetes have recently been elucidated. In particular, the central role of endoplasmic reticulum stress (ER stress) and the unfolding protein response (UPR) in insulin resistance in type 2 diabetes has recently been discovered. We hypothesize that ER stress and UPR are not only central for type 2 diabetes but also for stress-induced diabetes. We review here the evidence that post-burn insulin resistance and hyperglycaemia have pathophysiologic mechanisms in common with type 2 diabetes. These recent discoveries not only highlight the importance of ER stress in the post-burn patient recovery, but furthermore enable new models to study fundamental and interventional aspects of type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.