SynthesisOral diseases2011
Urban legends: recurrent aphthous stomatitis.
Synthesis in Oral diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- The efficacy of probiotics in management of recurrent aphthous stomatitis: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Pooled it
- Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review.Lasers in medical science · 2017Pooled it
- Low-level laser therapy in the treatment of recurrent aphthous ulcers: a systematic review.TheScientificWorldJournal · 2015Pooled it
- Interventions for the management of oral ulcers in Behçet's disease.The Cochrane database of systematic reviews · 2014Pooled it
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers).The Cochrane database of systematic reviews · 2012Pooled it
- Effect of Lozenges Containing Lactobacillus reuteri on the Severity of Recurrent Aphthous Ulcers: a Pilot Study.Probiotics and antimicrobial proteins · 2020Trial
- An evaluation of the efficacy of a topical gel with Triester Glycerol Oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: A randomized, double-blind, placebo-controlled clinical trial.Medicina oral, patologia oral y cirugia bucal · 2017Trial
- The safety and efficacy of AphtoFix® mouth ulcer cream in the management of recurrent aphthous stomatitis.BMC oral health · 2016Trial
- Clinical efficacy ofPakistan journal of medical sciences · 2025Article
- Recurrent Oral Ulcers: Are They Horses or Zebras?Cureus · 2024Article
- A Novel Therapeutic Approach of 980 nm Photobiomodulation Delivered with Flattop Beam Profile in Management of Recurrent Aphthous Stomatitis in Paediatrics and Adolescents-A Case Series with 3-Month Follow-Up.Journal of clinical medicine · 2024Article
- Knowledge of diagnosis and management of selected oral mucosal lesions among dentists in The Netherlands.Medicina oral, patologia oral y cirugia bucal · 2023Article
- Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease.Journal of clinical medicine · 2023Review
- Synthesis and functionalization of mucoadhesive mesoporous silica particles containing diphenhydramine for treatment of aphthous ulcers.BioImpacts : BI · 2023Article
- Article
- Evaluation of 5% Amlexenox Oral Paste and Rebamipide Tablets in Treatment of Recurrent Apthous Stomatitis and Comparison with Dologel CT.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Efficacy of Topical Intervention for Recurrent Aphthous Stomatitis: A Network Meta-Analysis.Medicina (Kaunas, Lithuania) · 2022Review
- A metagenome-wide association study of the gut microbiota in recurrent aphthous ulcer and regulation by thalidomide.Frontiers in immunology · 2022Article
- A Systematic Review and Meta-Analysis of Acupuncture Treatment for Oral Ulcer.Evidence-based complementary and alternative medicine : eCAM · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Recurrent aphthous stomatitis (RAS) is the most common idiopathic intraoral ulcerative disease in the USA. Aphthae typically occur in apparently healthy individuals, although an association with certain systemic diseases has been reported. Despite the unclear etiopathogenesis, new drug trials are continuously conducted in an attempt to reduce pain and dysfunction. We investigated four controversial topics: (1) Is complex aphthosis a mild form of Behçet's disease (BD)? (2) Is periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome a distinct medical entity? (3) Is RAS associated with other systemic diseases [e.g., celiac disease (CD) and B12 deficiency]? (4) Are there any new RAS treatments? Results from extensive literature searches, including a systematic review of RAS trials, suggested the following: (1) Complex aphthosis is not a mild form of BD in North America or Western Europe; (2) Diagnostic criteria for PFAPA have low specificity and the characteristics of the oral ulcers warrant further studies; (3) Oral ulcers may be associated with CD; however, these ulcers may not be RAS; RAS is rarely associated with B12 deficiency; nevertheless, B12 treatment may be beneficial, via mechanisms that warrant further study; (4) Thirty-three controlled trials published in the past 6 years reported some effectiveness, although potential for bias was high.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.