ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2011
The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02414477 (Metabolism of Deuterated NNN in Smokeless Tobacco Users), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolism of Deuterated NNN in Smokeless Tobacco Users
Who cites it
18 citing papers in PubMed.
- Diagnostic Performance Evaluation of the Novel Index Combining Urinary Cotinine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in Smoking Status Verification and Usefulness for Trend Monitoring of Tobacco Smoking Exposure.International journal of environmental research and public health · 2022Article
- Secondhand smoke exposure in school children in Malta assessed through urinary biomarkers.Environmental research · 2022Article
- High Levels of the Carcinogenic Tobacco-Specific Nitrosamine NNAL and Associated Findings in Children of Smokers: A Case Series.Biomarker insights · 2022Article
- Simultaneous analysis of urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, N'-nitrosonornicotine, and cotinine by liquid chromatography-tandem mass-spectrometry.Scientific reports · 2021Article
- Recent Developments in the Determination of Biomarkers of Tobacco Smoke Exposure in Biological Specimens: A Review.International journal of environmental research and public health · 2021Review
- Biochemical Verification of Tobacco Use and Abstinence: 2019 Update.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Review
- Comparison of Urine 4-(Methylnitrosamino)-1-(3)Pyridyl-1-Butanol and Cotinine for Assessment of Active and Passive Smoke Exposure in Urban Adolescents.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Tobacco, e-cigarettes, and child health.Current opinion in pediatrics · 2017Review
- Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second-generation and third-generation electronic cigarette users.Tobacco control · 2017Article
- Biomarkers of Tobacco Exposure: Summary of an FDA-Sponsored Public Workshop.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Evaluation of tobacco specific nitrosamines exposure by quantification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human hair of non-smokers.Scientific reports · 2016Article
- Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines.Accounts of chemical research · 2016Article
- Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Article
- Combined analysis of the tobacco metabolites cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine.Analytical chemistry · 2015Article
- Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.Carcinogenesis · 2014Article
- It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- High throughput liquid and gas chromatography-tandem mass spectrometry assays for tobacco-specific nitrosamine and polycyclic aromatic hydrocarbon metabolites associated with lung cancer in smokers.Chemical research in toxicology · 2013Article
- Simultaneous measurement of urinary total nicotine and cotinine as biomarkers of active and passive smoking among Japanese individuals.Environmental health and preventive medicine · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol plus its glucuronides (total NNAL), metabolites of the lung carcinogen NNK, and total cotinine, metabolites of nicotine, are biomarkers of active and passive cigarette smoking. We calculated the total NNAL:total cotinine (×10(3)) ratio in 408 passive (infants, children, and adults) and 1088 active smokers. The weighted averages were 0.73 (95% confidence interval 0.71, 0.76) for passive smokers and 0.07 (0.06, 0.08) for active smokers (p < 0.0001). These results demonstrate that cotinine measurements may underestimate exposure of passive smokers to the lung carcinogen NNK in second-hand cigarette smoke. The total NNAL:total cotinine (×10(3)) ratio may provide an improved biomarker for evaluating the health effects of passive smoking.
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