ReviewChemical research in toxicology2011
Exploring the biology of lipid peroxidation-derived protein carbonylation.
Review in Chemical research in toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- Deciphering Molecular Mechanisms of Carbon Tetrachloride- Induced Hepatotoxicity: A Brief Systematic Review.Current molecular medicine · 2024Pooled it
- Mild oxidative stress and dietary epigenetic modulators direct DNA methylation remodeling toward stress-resilience pathways.BMC genomics · 2026Article
- Cooperative Aldehyde Chemistry Maps an Orthogonal Lysine Reactivity Landscape.Journal of the American Chemical Society · 2026Article
- Effects of irradiation on microbiological safety and physicochemical properties of dry pet food.Journal of animal science and technology · 2026Article
- Metabolomics of Prostate Cancer and Clinical Profiles Following Radiotherapy: Need for a Precision Phylometabolomics Approach.Diagnostics (Basel, Switzerland) · 2025Article
- Protein oxidation in feed: Occurrence, monitoring, and mitigation strategies.Poultry science · 2025Review
- Macrophage Ferroptotic Resistance Is Required for the Progression of Infantile Hemangioma.Journal of the American Heart Association · 2025Article
- Genotoxic impact of agricultural insecticides as contaminants of river Teesta on the resident fish Pethia Conchonius.Scientific reports · 2024Article
- Circulatory Indicators of Lipid Peroxidation, the Driver of Ferroptosis, Reflect Differences between Relapsing-Remitting and Progressive Multiple Sclerosis.International journal of molecular sciences · 2024Article
- Excessive Lipid Peroxidation in Uterine Epithelium Causes Implantation Failure and Pregnancy Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Editorial: Insights in lipids, membranes and membranous organelles.Frontiers in molecular biosciences · 2023Article
- Quantitative profiling of PTM stoichiometry by resolvable mass tags.RSC chemical biology · 2022Article
- Contribution of Aldehydes and Their Derivatives to Antimicrobial and Immunomodulatory Activities.Molecules (Basel, Switzerland) · 2022Review
- FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Factors Affecting the Survival of Ram Spermatozoa during Liquid Storage and Options for Improvement.Animals : an open access journal from MDPI · 2022Review
- Profiling of Protein Carbonylations in Ferroptosis by Chemical Proteomics.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Proteome-wide analysis of hydrogen peroxide-induced protein carbonylation inFrontiers in plant science · 2022Article
- Oxidative Stress in Autism Spectrum Disorder-Current Progress of Mechanisms and Biomarkers.Frontiers in psychiatry · 2022Review
- Methylmercury-Induced Metabolic Alterations inToxics · 2021Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The sustained overproduction of reactive oxygen and nitrogen species results in an imbalance of cellular prooxidant-antioxidant systems and is implicated in numerous disease states, including alcoholic liver disease, cancer, neurological disorders, inflammation, and cardiovascular disease. The accumulation of reactive aldehydes resulting from sustained oxidative stress and lipid peroxidation is an underlying factor in the development of these pathologies. Determining the biochemical factors that elicit cellular responses resulting from protein carbonylation remains a key element to developing therapeutic approaches and ameliorating disease pathologies. This review details our current understanding of the generation of reactive aldehydes via lipid peroxidation resulting in protein carbonylation, focusing on pathophysiologic factors associated with 4-hydroxynonenal-protein modification. Additionally, an overview of in vitro and in vivo model systems used to study the physiologic impact of protein carbonylation is presented. Finally, an update of the methods commonly used in characterizing protein modification by reactive aldehydes provides an overview of isolation techniques, mass spectrometry, and computational biology. It is apparent that research in this area employing state-of-the-art proteomics, mass spectrometry, and computational biology is rapidly evolving, yielding foundational knowledge concerning the molecular mechanisms of protein carbonylation and its relation to a spectrum of diseases associated with oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.