ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2011
Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: a genetic analysis of comorbidity.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- GWA meta-analysis of personality in Korean cohorts.Journal of human genetics · 2015Pooled it
- Genome-wide analyses of borderline personality features.Molecular psychiatry · 2014Pooled it
- Psychological therapies for people with borderline personality disorder.The Cochrane database of systematic reviews · 2012Pooled it
- Borderline personality disorder and other psychiatric, somatic, and behavioral conditions: a nationwide family study.Translational psychiatry · 2026Article
- Brain iron distribution in transdiagnostic mental health burden.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Synaptic and Non-Synaptic Functions of PTPRD: A Receptor Tyrosine Phosphatase at the Crossroads of Neural Circuitry and Metabolism.Journal of neurochemistry · 2025Review
- Alternatively spliced mini-exon B in PTPδ regulates excitatory synapses through cell-type-specific trans-synaptic PTPδ-IL1RAP interaction.Nature communications · 2025Article
- Borderline personality: revisiting its classification as a neurodevelopmental disorder.Frontiers in psychiatry · 2025Review
- A Narrative Review of Outcomes, Comorbidities, and Alternative Behavioral Interventions in Adolescent and Adult Women with ADHD.International journal of women's health · 2025Review
- Dynamics of affect modulation in neurodevelopmental disorders (DynAMoND) - study design of a prospective cohort study.International journal of bipolar disorders · 2024Article
- Childhood symptoms of attention-deficit/hyperactivity disorder and borderline personality disorder.Acta psychiatrica Scandinavica · 2022Article
- Borderline personality disorder (BPD) and attention deficit hyperactivity disorder (ADHD) revisited - a review-update on common grounds and subtle distinctions.Borderline personality disorder and emotion dysregulation · 2021Review
- Familial risk and heritability of diagnosed borderline personality disorder: a register study of the Swedish population.Molecular psychiatry · 2021Article
- Do borderline personality disorder and attention-deficit/hyperactivity disorder co-aggregate in families? A population-based study of 2 million Swedes.Molecular psychiatry · 2021Article
- Distinct brain structure and behavior related to ADHD and conduct disorder traits.Molecular psychiatry · 2020Article
- Borderline Personality Traits Are Not Correlated With Brain Structure in Two Large Samples.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Splice-dependent trans-synaptic PTPδ-IL1RAPL1 interaction regulates synapse formation and non-REM sleep.The EMBO journal · 2020Article
- The role of environmental influences in the complex relationship between borderline personality disorder and attention-deficit/hyperactivity disorder: review of recent findings.Borderline personality disorder and emotion dysregulation · 2020Review
- Self-reported impulsivity in women with borderline personality disorder: the role of childhood maltreatment severity and emotion regulation difficulties.Borderline personality disorder and emotion dysregulation · 2019Article
- Attention Deficit Hyperactivity Disorder And Borderline Personality Disorder In Adults: A Review Of Their Links And Risks.Neuropsychiatric disease and treatment · 2019Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
Previous research has established the comorbidity of adult Attention-Deficit Hyperactivity Disorder (ADHD) with different personality disorders including Borderline Personality Disorder (BPD). The association between adult ADHD and BPD has primarily been investigated at the phenotypic level and not yet at the genetic level. The present study investigates the genetic and environmental contributions to the association between borderline personality traits (BPT) and ADHD symptoms in a sample of 7,233 twins and siblings (aged 18-90 years) registered with the Netherlands Twin Register and the East Flanders Prospective Twin Survey (EFPTS) . Participants completed the Conners' Adult ADHD Rating Scales (CAARS-S:SV) and the Personality Assessment Inventory-Borderline Features Scale (PAI-BOR). A bivariate genetic analysis was performed to determine the extent to which genetic and environmental factors influence variation in BPT and ADHD symptoms and the covariance between them. The heritability of BPT and ADHD symptoms was estimated at 45 and 36%, respectively. The remaining variance in BPT and ADHD symptoms was explained by unique environmental influences. The phenotypic correlation between BPT and ADHD symptoms was estimated at r = 0.59, and could be explained for 49% by genetic factors and 51% by environmental factors. The genetic and environmental correlations between BPT and ADHD symptoms were 0.72 and 0.51, respectively. The shared etiology between BPT and ADHD symptoms is thus a likely cause for the comorbidity of the two disorders.
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Registered trials
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