Evidence map›Paper›PMID 21812031›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011

Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research.

John P Bilezikian, Aliya Khan, John T Potts, Maria Luisa Brandi, Bart L Clarke, Dolores Shoback, Harald Jüppner, Pierre D'Amour, John Fox, Lars Rejnmark and 7 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03425747 (CALCIUM CITRATE vs CALCIUM CARBONATE FOR THE MANAGEMENT OF CHRONIC HYPOPARATHYROIDISM), which is not on this map. Cited by 233 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
233citing papers in PubMed, 7 pooled it
26.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03425747 phase4completednot on this mapstarted 2019, after this paper: background citation

CALCIUM CITRATE vs CALCIUM CARBONATE FOR THE MANAGEMENT OF CHRONIC HYPOPARATHYROIDISM

TypeinterventionalSponsorCampus Bio-Medico UniversityRan2019 to 2020Enrolled26ConditionsChronic HypoparathyroidismArmsCalcium Carbonate, Calcium Citrate
3 · Its place in the literature

Who cites it

233 citing papers in PubMed, 7 syntheses or guidelines pooled it, 609 citations in OpenAlex.

  1. Fluorescent Imaging in Thyroid Surgery to Preserve Parathyroid Function: A Systematic Review and Meta-Analysis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Pooled it
  2. Pooled it
  3. Safety and Efficacy of PTH 1-34 and 1-84 Therapy in Chronic Hypoparathyroidism: A Meta-Analysis of Prospective Trials.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Guideline
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26-Week Results From the Phase 3 PaTHway Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Trial
  12. Safety and Efficacy of Oral Human Parathyroid Hormone (1-34) in Hypoparathyroidism: An Open-Label Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Trial
  13. The Effects of Long-term Administration of rhPTH(1-84) in Hypoparathyroidism by Bone Histomorphometry.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Trial
  14. Trial
  15. Trial
  16. Trial
  17. Effects of Parathyroid Hormone Administration on Bone Strength in Hypoparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Trial
  18. Noninvasive Assessment of Skeletal Microstructure and Estimated Bone Strength in Hypoparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Trial
  19. Article
  20. Review

173 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 4 countries.

John P BilezikianDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. jpb2@columbia.edu
Aliya Khan
John T Potts
Maria Luisa Brandi
Bart L Clarke
Dolores Shoback
Harald Jüppner
Pierre D'Amour
John Fox
Lars Rejnmark
Leif Mosekilde
Mishaela R Rubin
David Dempster
Rachel Gafni
Michael T Collins
Jim Sliney
James Sanders
Columbia University · USAarhus University Hospital · DKNational Institute of Dental and Craniofacial Research · USHarvard University · USHelen Hayes Hospital · USMassachusetts General Hospital · USMayo Clinic in Arizona · USMcMaster University · CASan Francisco VA Medical Center · USUniversité de Montréal · CAUniversity of Florence · IT

Funding

Skeletal Disorders and Mineral Homeostasis SectionZIADE000649 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI COLLINS, MICHAEL · 2009 to 2025
$32.8M
BONE PROPERTIES IN HYPOPARATHYROIDISM: EFFECTS OF PTHR01DK069350 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BILEZIKIAN, JOHN P · 2005 to 2014
$6.1M
Molecular Definition of PseudohypoparathyroidismR37DK046718 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JUEPPNER, HARALD W. · 2002 to 2011
$4.0M
FDA HHS R01 FD002525NIDDK NIH HHS DK069350NIDDK NIH HHS R01 DK069350NIDDK NIH HHS R37 DK046718NIDDK NIH HHS R37 DK46718
6 · The paper itself

Abstract

Recent advances in understanding the epidemiology, genetics, diagnosis, clinical presentations, skeletal involvement, and therapeutic approaches to hypoparathyroidism led to the First International Workshop on Hypoparathyroidism that was held in 2009. At this conference, a group of experts convened to discuss these issues with a view towards a future research agenda for this disease. This review, which focuses primarily on hypoparathyroidism in the adult, provides a comprehensive summary of the latest information on this disease.

Indexed as

HypoparathyroidismAdultHumans

Identifiers

PMID21812031
PMCPMC3405491
OpenAlexW2083586358

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.