ArticleDiabetologia2011
Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats.
Article in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Sinapine Modulates Glycogen and Lipid Synthesis via IRS1-PI3K-AKT-GSK3β-GS Pathway in Insulin-Resistant Models.Food science & nutrition · 2026Article
- Active Glycogen Synthase in the Liver Prevents High-Fat Diet-Induced Glucose Intolerance, Decreases Food Intake, and Lowers Body Weight.International journal of molecular sciences · 2023Article
- Dendropanoxide Alleviates Thioacetamide-induced Hepatic Fibrosis via Inhibition of ROS Production and Inflammation in BALB/International journal of biological sciences · 2023Article
- Therapeutic Potentials ofJournal of inflammation research · 2021Article
- Maintenance of liver glycogen during long-term fasting preserves energy state in mice.FEBS letters · 2020Article
- Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5' adenosine monophosphate kinase up-regulation.Saudi journal of biological sciences · 2019Article
- Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers.Metabolic brain disease · 2018Article
- Melatonin attenuates smoking-induced hyperglycemia via preserving insulin secretion and hepatic glycogen synthesis in rats.Journal of pineal research · 2018Article
- Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice.The Journal of biological chemistry · 2017Article
- Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice.Diabetologia · 2017Article
- Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance.Molecular and cellular biology · 2016Article
- 1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice.Molecules (Basel, Switzerland) · 2016Article
- High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications.Nutrition & metabolism · 2016Article
- Over-expression of muscle glycogen synthase in human diabetic nephropathy.Histochemistry and cell biology · 2015Article
- Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity.Journal of translational medicine · 2014Article
- Pathway-selective insulin resistance and metabolic disease: the importance of nutrient flux.The Journal of biological chemistry · 2014Review
- Article
- Increasing hepatic glycogen moderates the diabetic phenotype in insulin-deficient Akita mice.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisGlycogen deposition is impaired in diabetes, thus contributing to the development of hyperglycaemia. Several glucose-lowering strategies have attempted to increase liver glycogen deposition by modulating targets, which eventually trigger the activation of liver glycogen synthase (LGS). However, these targets also alter several other biological processes, and therefore their therapeutic use may be limited. Here we tested the approach of directly activating LGS and evaluated the potential of this strategy as a possible treatment for diabetes.
methodsIn this study, we examined the efficacy of directly overproducing a constitutively active form of LGS in the liver to ameliorate streptozotocin-induced diabetes in rats.
resultsActivated mutant LGS overproduction in the liver of streptozotocin-induced diabetic rats normalised liver glycogen content, despite low levels of glucokinase and circulating insulin. Moreover, this overproduction led to a decrease in food intake and in the production of the main gluconeogenic enzymes, glucose-6-phosphatase, fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase. The resulting combined effect was a reduction in hyperglycaemia. CONCLUSIONS/
interpretationThe restoration of liver glycogen ameliorated diabetes and therefore is considered a potential strategy for the treatment of this disease.
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