SynthesisDiabetologia2012
Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adults.
Synthesis in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- The effect of selective serotonin re-uptake inhibitors on risk of type II diabetes mellitus and acute pancreatitis: a meta-analysis.Bioscience reports · 2018Pooled it
- The risk of new-onset diabetes in antidepressant users - A systematic review and meta-analysis.PloS one · 2017Pooled it
- Antidepressant medication as a risk factor for type 2 diabetes and impaired glucose regulation: systematic review.Diabetes care · 2013Pooled it
- Antidepressant use and new-onset diabetes: a systematic review and meta-analysis.Diabetes/metabolism research and reviews · 2013Pooled it
- Community-based diabetes prevention randomized controlled trial in refugees with depression: effects on metabolic outcomes and depression.Scientific reports · 2023Trial
- Weight and metabolic effects of dietary weight loss and exercise interventions in postmenopausal antidepressant medication users and non-users: a randomized controlled trial.Preventive medicine · 2013Trial
- Article
- The role of ultra-processed food consumption and depression on type 2 diabetes incidence: a prospective community study in Quebec, Canada.Public health nutrition · 2023Article
- Pancreatic cancer is associated with medication changes prior to clinical diagnosis.Nature communications · 2023Article
- Silymarin attenuates escitalopram (cipralex) induced pancreatic injury in adult male albino rats: a biochemical, histological, and immunohistochemical approach.Anatomy & cell biology · 2023Article
- Review
- Article
- Association between Depression, Antidepression Medications, and the Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study in Taiwan.BioMed research international · 2021Article
- The association of depression with metabolic syndrome parameters and malondialdehyde (MDA) in obese women: A case-control study.Health promotion perspectives · 2021Article
- Is There Limited Utility for Lifestyle Recommendations for Diabetes Prevention Among Overweight or Obese Depressed Patients?Frontiers in medicine · 2021Article
- Association of Selective Serotonin Reuptake Inhibitors With the Risk of Type 2 Diabetes in Children and Adolescents.JAMA psychiatry · 2021Article
- Repurposing Doxepin to Ameliorate Steatosis and Hyperglycemia by Activating FAM3A Signaling Pathway.Diabetes · 2020Article
- Role of Serotonin Transporter in Antidepressant-Induced Diabetes Mellitus: A Pharmacoepidemiological-Pharmacodynamic Study in VigiBaseDrug safety · 2018Article
- Trajectory of Disability in Older Adults With Newly Diagnosed Diabetes: Role of Elevated Depressive Symptoms.Diabetes care · 2018Article
- Association between major depressive episode and risk of type 2 diabetes: A large prospective cohort study in Chinese adults.Journal of affective disorders · 2018Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
aims/hypothesisThe results of several studies have suggested a potential positive association between use of antidepressant medication (ADM) and incident type 2 diabetes mellitus. We examined this association in three cohorts of US adults.
methodsWe followed 29,776 men in the Health Professionals Follow-up Study (HPFS, 1990-2006), 61,791 women in the Nurses' Health Study I (NHS I, 1996-2008) and 76,868 women in NHS II (1993-2005), who were free of diabetes mellitus, cardiovascular disease or cancer at baseline. The mean baseline ages for participants from the HPFS and NHS I and II were 56.4, 61.3 and 38.1 years, respectively. ADM use and other covariates were assessed at baseline and updated every 2 years. A time-dependent Cox proportional hazards model was used, and HRs were pooled together across the three cohorts.
resultsDuring 1,644,679 person-years of follow-up, we documented 6,641 new cases of type 2 diabetes. ADM use was associated with an increased risk of diabetes in all three cohorts in age-adjusted models (pooled HR 1.68 [95% CI 1.27, 2.23]). The association was attenuated after adjustment for diabetes risk factors and histories of high cholesterol and hypertension (1.30 [1.14, 1.49]), and further attenuated by controlling for updated BMI (1.17 [1.09, 1.25]). Use of selective serotonin reuptake inhibitors and other antidepressants (mainly tricyclic antidepressants) were both associated with an elevated risk of diabetes, with pooled multivariate-adjusted HRs of 1.10 (1.00, 1.22) and 1.26 (1.11, 1.42), respectively. CONCLUSIONS/
interpretationThe results suggest that ADM users had a moderately elevated risk of type 2 diabetes mellitus compared with non-users, even after adjustment for BMI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.