ArticleInternational urogynecology journal2012
Pelvic organ prolapse and collagen-associated disorders.
Article in International urogynecology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Type III Collagen RNA Level Expression in Pelvic Organ Prolapse: A Systematic Review and Meta-Analysis.International urogynecology journal · 2024Pooled it
- PEOPLE: Lifestyle and comorbidities as risk factors for pelvic organ prolapse-a systematic review and meta-analysis PEOPLE: PElvic Organ Prolapse Lifestyle comorbiditiEs.International urogynecology journal · 2023Pooled it
- The difference in collagen type-1 expression in women with and without pelvic organ prolapse: a systematic review and meta-analysis.International urogynecology journal · 2022Pooled it
- Association between joint hypermobility and pelvic organ prolapse in women: a systematic review and meta-analysis.International urogynecology journal · 2016Pooled it
- Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women.American journal of obstetrics and gynecology · 2015Pooled it
- Connective tissue and genetics in the pathogenesis of rectal prolapse: A scoping review.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Evidence of compensatory elastin remodeling in non-prolapsed uterosacral ligaments and its divergence in histopathological subtypes of pelvic organ prolapse.BMC women's health · 2026Article
- Shift work and hormonal-circadian disruption raise urinary incontinence: a narrative review.Gynecology and pelvic medicine · 2026Review
- Advanced Uterine Prolapse in a Primiparous Postmenopausal Woman Successfully Treated with Total Vaginal Hysterectomy: A Case Report.International medical case reports journal · 2026Article
- Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026Review
- Recurrent Rectal Prolapse.Clinics in colon and rectal surgery · 2025Review
- Family history and acquired risk factors for pelvic organ prolapse: a case-control study in Japan.Scientific reports · 2025Article
- COL3A1 Gene Polymorphism and Its Impact on Female Pelvic Organ Prolapse.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Identification of Novel Disease-Modifying Agents for Pelvic Organ Prolapse by Systematic Druggable Genome-Wide Mendelian Randomization.International journal of women's health · 2025Article
- Anterior pelvic organ prolapse repair: the intersection of science and art.Gynecology and pelvic medicine · 2024Article
- Article
- Clinical characteristics of patients with hypermobile type Ehlers-Danlos syndrome (hEDS) and generalized hypermobility spectrum disorders (G-HSD): an online survey.Rheumatology international · 2023Article
- Anorectal manometry for the diagnosis of pelvic floor disorders in patients with hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome.BMC gastroenterology · 2022Article
- Transanal rectopexy for external rectal prolapse.Annals of coloproctology · 2022Article
- Ehlers-Danlos: A Literature Review and Case Report in a Colombian Woman with Multiple Comorbidities.Genes · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisPelvic organ prolapse (POP) and other disorders, such as varicose veins and joint hypermobility, have been associated with changes in collagen strength and metabolism. We hypothesized that these various disorders were more prevalent in both POP patients and their family members.
methodsIn this study, the prevalence of various collagen-associated disorders, including POP, was compared between POP patients (n = 110) and control patients (n = 100) and their first and second degree family members.
resultsPOP patients reported a higher prevalence of varicose veins, joint hypermobility and rectal prolapse and were more likely to have family members with POP as compared to the control group (p < 0.01). In contrast, the family members of the POP group did not report a higher prevalence of collagen-associated disorders compared to the family members of the control group (p = 0.82).
conclusionsPOP and other collagen-associated disorders may have a common aetiology, originating at the molecular level of the collagens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.