ArticlePloS one2011
Adipose tissue fatty acid patterns and changes in anthropometry: a cohort study.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Associations of Plasma Fatty Acid Patterns During Pregnancy With Gestational Diabetes Mellitus.Frontiers in nutrition · 2022Article
- Statement on additional scientific evidence in relation to the essential composition of total diet replacement for weight control.EFSA journal. European Food Safety Authority · 2021Article
- Association of plasma phospholipid polyunsaturated and trans fatty acids with body mass index: results from the Multi-Ethnic Study of Atherosclerosis.International journal of obesity (2005) · 2018Article
- Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study.PloS one · 2018Article
- A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study.PLoS medicine · 2017Article
- Associations of erythrocyte fatty acid patterns with insulin resistance.The American journal of clinical nutrition · 2016Article
- Baseline patterns of adipose tissue fatty acids and long-term risk of breast cancer: a case-cohort study in the Danish cohort Diet, Cancer and Health.European journal of clinical nutrition · 2014Article
- Women's higher health risks in the obesogenic environment: a gender nutrition approach to metabolic dimorphism with predictive, preventive, and personalised medicine.The EPMA journal · 2013Article
- Novel circulating fatty acid patterns and risk of cardiovascular disease: the Cardiovascular Health Study.The American journal of clinical nutrition · 2012Article
- An overview of the contribution of fatness and fitness factors, and the role of exercise, in the formation of health status for individuals who are overweight.Journal of diabetes and metabolic disorders · 2012Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDiets rich in n-3 long chain polyunsaturated fatty acids (LC-PUFA), but low in n-6 LC-PUFA and 18:1 trans-fatty acids (TFA), may lower the risk of overweight and obesity. These fatty acids have often been investigated individually. We explored associations between global patterns in adipose tissue fatty acids and changes in anthropometry.
methods34 fatty acid species from adipose tissue biopsies were determined in a random sample of 1100 men and women from a Danish cohort study. We used sex-specific principal component analysis and multiple linear regression to investigate the associations of adipose tissue fatty acid patterns with changes in weight, waist circumference (WC), and WC controlled for changes in body mass index (WC(BMI)), adjusting for confounders.
results7 principal components were extracted for each sex, explaining 77.6% and 78.3% of fatty acid variation in men and women, respectively. Fatty acid patterns with high levels of TFA tended to be positively associated with changes in weight and WC for both sexes. Patterns with high levels of n-6 LC-PUFA tended to be negatively associated with changes in weight and WC in men, and positively associated in women. Associations with patterns with high levels of n-3 LC-PUFA were dependent on the context of the rest of the fatty acid pattern.
conclusionsAdipose tissue fatty acid patterns with high levels of TFA may be linked to weight gain, but patterns with high n-3 LC-PUFA did not appear to be linked to weight loss. Associations depended on characteristics of the rest of the pattern.
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