Trial reportPloS one2011
The effect of pulmonary artery catheter use on costs and long-term outcomes of acute lung injury.
Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00234767 (Economic Analysis of Pulmonary Artery Catheter Use), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Economic Analysis of Pulmonary Artery Catheter Use (EA-PAC)
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Health Economic Evaluations in Intensive Care: An Updated Systematic Review.Critical care explorations · 2025Pooled it
- The association of pulmonary artery catheterization utilization and surgical patients' outcomes: a PRISMA-compliant systematic review and meta-analysis.Journal of cardiothoracic surgery · 2025Pooled it
- Relationship between Race and the Effect of Fluids on Long-term Mortality after Acute Respiratory Distress Syndrome. Secondary Analysis of the National Heart, Lung, and Blood Institute Fluid and Catheter Treatment Trial.Annals of the American Thoracic Society · 2017Trial
- The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury.American journal of respiratory and critical care medicine · 2012Trial
- Trial
- Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock.Intensive care medicine · 2023Article
- Development and perceived usability evaluation of an interactive smartphone application for the teaching of hemodynamics and evaluation of arterial pulse pressure variation.BMC medical informatics and decision making · 2023Article
- Discharge Destination As a Marker of Mobility Impairment in Survivors of Acute Respiratory Distress Syndrome.Critical care medicine · 2019Observational
- Article
- Fluid Management in Acute Respiratory Distress Syndrome: Do We Have All the FACTTs to Determine the Effect of Race?Annals of the American Thoracic Society · 2017Article
- Healthcare utilization and costs in ARDS survivors: a 1-year longitudinal national US multicenter study.Intensive care medicine · 2017Article
- Getting down to the real question: effects of transfusion triggers on long-term survival and quality of life following septic shock.Intensive care medicine · 2016Article
- Development and Validation of a Mortality Prediction Model for Patients Receiving 14 Days of Mechanical Ventilation.Critical care medicine · 2015Article
- Review
- Health care resource use and costs of two-year survivors of acute lung injury. An observational cohort study.Annals of the American Thoracic Society · 2015Observational
- Can we optimize long-term outcomes in acute respiratory distress syndrome by targeting normoxemia?Annals of the American Thoracic Society · 2014Article
- One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome.Intensive care medicine · 2014Article
- The pulmonary artery catheter.Journal of clinical monitoring and computing · 2012Review
- Article
- Cardiac output measured by transthoracic echocardiography and Swan-Ganz catheter. A comparative study in mechanically ventilated patients with high positive end-expiratory pressure.Revista Brasileira de terapia intensivaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThe pulmonary artery catheter (PAC) remains widely used in acute lung injury (ALI) despite known complications and little evidence of improved short-term mortality. Concurrent with NHLBI ARDS Clinical Trials Network Fluid and Catheters Treatment Trial (FACTT), we conducted a prospectively-defined comparison of healthcare costs and long-term outcomes for care with a PAC vs. central venous catheter (CVC). We explored if use of the PAC in ALI is justified by a beneficial cost-effectiveness profile.
methodsWe obtained detailed bills for the initial hospitalization. We interviewed survivors using the Health Utilities Index Mark 2 questionnaire at 2, 6, 9 and 12 m to determine quality of life (QOL) and post-discharge resource use. Outcomes beyond 12 m were estimated from federal databases. Incremental costs and outcomes were generated using MonteCarlo simulation.
resultsOf 1001 subjects enrolled in FACTT, 774 (86%) were eligible for long-term follow-up and 655 (85%) consented. Hospital costs were similar for the PAC and CVC groups ($96.8k vs. $89.2k, p = 0.38). Post-discharge to 12 m costs were higher for PAC subjects ($61.1k vs. 45.4k, p = 0.03). One-year mortality and QOL among survivors were similar in PAC and CVC groups (mortality: 35.6% vs. 31.9%, p = 0.33; QOL [scale: 0-1]: 0.61 vs. 0.66, p = 0.49). MonteCarlo simulation showed PAC use had a 75.2% probability of being more expensive and less effective (mean cost increase of $14.4k and mean loss of 0.3 quality-adjusted life years (QALYs)) and a 94.2% probability of being higher than the $100k/QALY willingness-to-pay threshold.
conclusionPAC use increased costs with no patient benefit and thus appears unjustified for routine use in ALI.
trial registrationwww.clinicaltrials.gov NCT00234767.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.