ArticlePloS one2011
Allorecognition in the Tasmanian devil (Sarcophilus harrisii), an endangered marsupial species with limited genetic diversity.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Macroimmunology: The drivers and consequences of spatial patterns in wildlife immune defence.The Journal of animal ecology · 2020Pooled it
- Is chimerism associated with cancer across the tree of life?PloS one · 2023Article
- Expression of the Nonclassical MHC Class I, Saha-UD in the Transmissible Cancer Devil Facial Tumour Disease (DFTD).Pathogens (Basel, Switzerland) · 2022Article
- The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers.PLoS pathogens · 2021Article
- Applied ecoimmunology: using immunological tools to improve conservation efforts in a changing world.Conservation physiology · 2021Article
- Curse of the devil: molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii).Cellular and molecular life sciences : CMLS · 2020Review
- A Devil of a Transmissible Cancer.Tropical medicine and infectious disease · 2020Review
- Cooperative inflammation: The recruitment of inflammatory signaling in marsupial and eutherian pregnancy.Journal of reproductive immunology · 2020Review
- Transmissible Cancers and Immune Downregulation in Tasmanian Devil (Comparative medicine · 2019Article
- Fecal Viral Diversity of Captive and Wild Tasmanian Devils Characterized Using Virion-Enriched Metagenomics and Metatranscriptomics.Journal of virology · 2019Article
- Tasmanian devils with contagious cancer exhibit a constricted T-cell repertoire diversity.Communications biology · 2019Article
- Two Decades of the Impact of Tasmanian Devil Facial Tumor Disease.Integrative and comparative biology · 2018Article
- Lessons learnt from the Tasmanian devil facial tumour regarding immune function in cancer.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Conservation of biodiversity in the genomics era.Genome biology · 2018Review
- Dental Pulp Stem Cells - Exploration in a Novel Animal Model: the Tasmanian Devil (Sarcophilus harrisii).Stem cell reviews and reports · 2018Review
- The devil is in the details: Genomics of transmissible cancers in Tasmanian devils.PLoS pathogens · 2018Article
- Article
- Immunization Strategies Producing a Humoral IgG Immune Response against Devil Facial Tumor Disease in the Majority of Tasmanian Devils Destined for Wild Release.Frontiers in immunology · 2018Article
- The role of MHC genes in contagious cancer: the story of Tasmanian devils.Immunogenetics · 2017Review
- Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tasmanian devils (Sarcophilus harrisii) are on the verge of extinction due to a transmissible cancer, devil facial tumour disease (DFTD). This tumour is an allograft that is transmitted between individuals without immune recognition of the tumour cells. The mechanism to explain this lack of immune recognition and acceptance is not well understood. It has been hypothesized that lack of genetic diversity at the Major Histocompatibility Complex (MHC) allowed the tumour cells to grow in genetically similar hosts without evoking an immune response to alloantigens. We conducted mixed lymphocyte reactions and skin grafts to measure functional MHC diversity in the Tasmanian devil population. The limited MHC diversity was sufficient to produce measurable mixed lymphocyte reactions. There was a wide range of responses, from low or no reaction to relatively strong responses. The highest responses occurred when lymphocytes from devils from the east of Tasmania were mixed with lymphocytes from devils from the west of Tasmania. All of the five successful skin allografts were rejected within 14 days after surgery, even though little or no MHC I and II mismatches were found. Extensive T-cell infiltration characterised the immune rejection. We conclude that Tasmanian devils are capable of allogeneic rejection. Consequently, a lack of functional allorecognition mechanisms in the devil population does not explain the transmission of a contagious cancer.
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Registered trials
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