ArticlePloS one2011
Experimental meningococcal sepsis in congenic transgenic mice expressing human transferrin.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Pooled it
- Pooled it
- Abdominal symptoms of invasive meningococcal disease are associated with the induction of plasminogen activator inhibitor-1 in omental adipocytes.BMC infectious diseases · 2026Article
- Inactivation of the porB gene reduces the virulence of Neisseria meningitidis in transgenic mice.BMC microbiology · 2025Article
- Vertebrate and Invertebrate Animal and New In Vitro Models for StudyingPathogens (Basel, Switzerland) · 2023Review
- Exploring the Ability of Meningococcal Vaccines to Elicit Mucosal Immunity: Insights from Humans and Mice.Pathogens (Basel, Switzerland) · 2021Review
- Sodium Tetraphenylborate Displays Selective Bactericidal Activity against Neisseria meningitidis and N. gonorrhoeae and Is Effective at Reducing Bacterial Infection Load.Antimicrobial agents and chemotherapy · 2021Article
- Evidence for Multi-Organ Infection During Experimental Meningococcal Sepsis due to ST-11 Isolates in Human Transferrin-Transgenic Mice.Microorganisms · 2020Article
- Difference in virulence between Neisseria meningitidis serogroups W and Y in transgenic mice.BMC microbiology · 2020Article
- Article
- Article
- Differential protein expression in patients with urosepsis.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Article
- Lactobacillus paracasei feeding improves the control of secondary experimental meningococcal infection in flu-infected mice.BMC infectious diseases · 2018Article
- Lactobacillus paracasei feeding improves immune control of influenza infection in mice.PloS one · 2017Article
- Use of Animal Models To Support Revising Meningococcal Breakpoints of β-Lactams.Antimicrobial agents and chemotherapy · 2016Article
- Neisseria meningitidis Serogroup X in Sub-Saharan Africa.Emerging infectious diseases · 2016Article
- Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model.Infection and immunity · 2014Article
- Lipocalin 2 in cerebrospinal fluid as a marker of acute bacterial meningitis.BMC infectious diseases · 2014Article
- Pyrophosphate-mediated iron acquisition from transferrin in Neisseria meningitidis does not require TonB activity.PloS one · 2014Article
- Target gene sequencing to define the susceptibility of Neisseria meningitidis to ciprofloxacin.Antimicrobial agents and chemotherapy · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe meningococcal sepsis is still of high morbidity and mortality. Its management may be improved by an experimental model allowing better understanding of its pathophysiology. We developed an animal model of meningococcal sepsis in transgenic BALB/c mice expressing human transferrin. We studied experimental meningococcal sepsis in congenic transgenic BALB/c mice expressing human transferrin by transcriptional profiling using microarray analysis of blood and brain samples. Genes encoding acute phase proteins, chemokines and cytokines constituted the largest strongly regulated groups. Dynamic bioluminescence imaging further showed high blood bacterial loads that were further enhanced after a primary viral infection by influenza A virus. Moreover, IL-1 receptor-associated kinase-3 (IRAK-3) was induced in infected mice. IRAK-3 is a negative regulator of Toll-dependant signaling and its induction may impair innate immunity and hence result in an immunocompromised state allowing bacterial survival and systemic spread during sepsis. This new approach should enable detailed analysis of the pathophysiology of meningococcal sepsis and its relationships with flu infection.
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Registered trials
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