ArticlePloS one2011
Differential gene expression by RamA in ciprofloxacin-resistant Salmonella Typhimurium.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Plasmid-borne transcriptional regulator RamAp modulatesFrontiers in microbiology · 2026Article
- Employing diclofenac sodium as a novel therapeutic frontier for Staphylococcus epidermidis infections.Scientific reports · 2025Article
- Antibiotic-induced stress responses in Gram-negative bacteria and their role in antibiotic resistance.The Journal of antimicrobial chemotherapy · 2025Review
- RamA upregulates the ATP-binding cassette transporterMicrobiology spectrum · 2025Article
- Article
- Bacterial Stress Responses as Potential Targets in Overcoming Antibiotic Resistance.Microorganisms · 2022Review
- Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Antidiarrheal and Antibacterial Activities of Monterey Cypress Phytochemicals: In Vivo and In Vitro Approach.Molecules (Basel, Switzerland) · 2022Article
- Elucidation of Phytochemical Content ofAntibiotics (Basel, Switzerland) · 2021Article
- Antibacterial Activity ofAntibiotics (Basel, Switzerland) · 2021Article
- Transcriptional Regulation of the Multiple Resistance Mechanisms inPathogens (Basel, Switzerland) · 2021Review
- Article
- Transcriptional regulation of drug resistance mechanisms in Salmonella: where we stand and what we need to know.World journal of microbiology & biotechnology · 2020Review
- Overexpression of RamA, Which Regulates Production of the Multidrug Resistance Efflux Pump AcrAB-TolC, Increases Mutation Rate and Influences Drug Resistance Phenotype.Antimicrobial agents and chemotherapy · 2020Article
- MarA, RamA, and SoxS as Mediators of the Stress Response: Survival at a Cost.Frontiers in microbiology · 2020Article
- Biolog Phenotype Microarray Is a Tool for the Identification of Multidrug Resistance Efflux Pump Inducers.Antimicrobial agents and chemotherapy · 2018Article
- Characterization of β-lactamase- and efflux pump-mediated multiple antibiotic resistance inFood science and biotechnology · 2018Article
- Efflux Pump Overexpression Contributes to Tigecycline Heteroresistance inFrontiers in cellular and infection microbiology · 2017Article
- Exposure of Salmonella enterica Serovar Typhimurium to Three Humectants Used in the Food Industry Induces Different Osmoadaptation Systems.Applied and environmental microbiology · 2015Article
- Elucidation of the RamA regulon in Klebsiella pneumoniae reveals a role in LPS regulation.PLoS pathogens · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression of ramA has been implicated in resistance to multiple drugs in several enterobacterial pathogens. In the present study, Salmonella Typhimurium strain LTL with constitutive expression of ramA was compared to its ramA-deletion mutant by employing both DNA microarrays and phenotype microarrays (PM). The mutant strain with the disruption of ramA showed differential expression of at least 33 genes involved in 11 functional groups. The study confirmed at the transcriptional level that the constitutive expression of ramA was directly associated with increased expression of multidrug efflux pump AcrAB-TolC and decreased expression of porin protein OmpF, thereby conferring multiple drug resistance phenotype. Compared to the parent strain constitutively expressing ramA, the ramA mutant had increased susceptibility to over 70 antimicrobials and toxic compounds. The PM analysis also uncovered that the ramA mutant was better in utilization of 10 carbon sources and 5 phosphorus sources. This study suggested that the constitutive expression of ramA locus regulate not only multidrug efflux pump and accessory genes but also genes involved in carbon metabolic pathways.
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