ArticlePLoS genetics2011
Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- ThemicroPublication biology · 2025Article
- A taxon-restricted duplicate of Iroquois3 is required for patterning the spider waist.PLoS biology · 2024Article
- Review
- Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase.International journal of molecular sciences · 2021Article
- Review
- Iroquois Homeodomain transcription factors in ventricular conduction system and arrhythmia.International journal of medical sciences · 2018Review
- Differential Cellular Responses to Hedgehog Signalling in Vertebrates-What is the Role of Competence?Journal of developmental biology · 2016Review
- The Homeodomain Iroquois Proteins Control Cell Cycle Progression and Regulate the Size of Developmental Fields.PLoS genetics · 2015Article
- Controlled expression of Drosophila homeobox loci using the Hostile takeover system.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Muscle cell fate choice requires the T-box transcription factor midline in Drosophila.Genetics · 2015Article
- Expanding the Iroquois genes repertoire: a non-transcriptional function in cell cycle progression.Fly · 2015Article
- Whole-genome analysis of muscle founder cells implicates the chromatin regulator Sin3A in muscle identity.Cell reports · 2014Article
- The Iroquois complex is required in the dorsal mesoderm to ensure normal heart development in Drosophila.PloS one · 2013Article
- Article
- An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement.Genome research · 2012Article
- Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification.Development (Cambridge, England) · 2012Article
- Specification of the somatic musculature in Drosophila.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A central issue of myogenesis is the acquisition of identity by individual muscles. In Drosophila, at the time muscle progenitors are singled out, they already express unique combinations of muscle identity genes. This muscle code results from the integration of positional and temporal signalling inputs. Here we identify, by means of loss-of-function and ectopic expression approaches, the Iroquois Complex homeobox genes araucan and caupolican as novel muscle identity genes that confer lateral transverse muscle identity. The acquisition of this fate requires that Araucan/Caupolican repress other muscle identity genes such as slouch and vestigial. In addition, we show that Caupolican-dependent slouch expression depends on the activation state of the Ras/Mitogen Activated Protein Kinase cascade. This provides a comprehensive insight into the way Iroquois genes integrate in muscle progenitors, signalling inputs that modulate gene expression and protein activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.