ArticlePLoS biology2011
Coupled evolution of transcription and mRNA degradation.
Article in PLoS biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Biophysical constraints on mRNA decay rates shape macroevolutionary divergence in steady-state abundances.bioRxiv : the preprint server for biology · 2025Article
- Enhanced gene regulation by cooperation between mRNA decay and gene transcription.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023Article
- Article
- Review
- Independent evolution of transcript abundance and gene regulatory dynamics.Genome research · 2020Article
- Genomewide Stabilization of mRNA during a "Feast-to-Famine" Growth Transition in Escherichia coli.mSphere · 2020Article
- Gene regulatory network stabilized by pervasive weak repressions: microRNA functions revealed by the May-Wigner theory.National science review · 2019Article
- Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming.Nature communications · 2019Article
- Molecular Chaperones Accelerate the Evolution of Their Protein Clients in Yeast.Genome biology and evolution · 2019Article
- Pervasive function and evidence for selection across standing genetic variation in S. cerevisiae.Nature communications · 2019Article
- Direct measurement of pervasive weak repression by microRNAs and their role at the network level.BMC genomics · 2018Article
- Pervasive allele-specific regulation on RNA decay in hybrid mice.Life science alliance · 2018Article
- Antisense transcription-dependent chromatin signature modulates sense transcript dynamics.Molecular systems biology · 2018Article
- The interplay between transcription and mRNA degradation inMicrobial cell (Graz, Austria) · 2017Review
- Multiplexed gene control reveals rapid mRNA turnover.Science advances · 2017Article
- Cell types differ in global coordination of splicing and proportion of highly expressed genes.Scientific reports · 2016Article
- Translational Capacity of a Cell Is Determined during Transcription Elongation via the Ccr4-Not Complex.Cell reports · 2016Article
- Coordinated Evolution of Transcriptional and Post-Transcriptional Regulation for Mitochondrial Functions in Yeast Strains.PloS one · 2016Article
- Next-generation analysis of gene expression regulation--comparing the roles of synthesis and degradation.Molecular bioSystems · 2015Review
- Sex Bias and Maternal Contribution to Gene Expression Divergence in Drosophila Blastoderm Embryos.PLoS genetics · 2015Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
mRNA levels are determined by the balance between transcription and mRNA degradation, and while transcription has been extensively studied, very little is known regarding the regulation of mRNA degradation and its coordination with transcription. Here we examine the evolution of mRNA degradation rates between two closely related yeast species. Surprisingly, we find that around half of the evolutionary changes in mRNA degradation were coupled to transcriptional changes that exert opposite effects on mRNA levels. Analysis of mRNA degradation rates in an interspecific hybrid further suggests that opposite evolutionary changes in transcription and in mRNA degradation are mechanistically coupled and were generated by the same individual mutations. Coupled changes are associated with divergence of two complexes that were previously implicated both in transcription and in mRNA degradation (Rpb4/7 and Ccr4-Not), as well as with sequence divergence of transcription factor binding motifs. These results suggest that an opposite coupling between the regulation of transcription and that of mRNA degradation has shaped the evolution of gene regulation in yeast.
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