ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2011
Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern Tanzania.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 5 of them syntheses that pooled it.
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Who cites it
83 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Prevalence of fever of unidentified aetiology in East African adolescents and adults: a systematic review and meta-analysis.Infectious diseases of poverty · 2023Pooled it
- A systematic review and meta-analysis of the aetiological agents of non-malarial febrile illnesses in Africa.PLoS neglected tropical diseases · 2022Pooled it
- Selection of Diagnostic Cutoffs for Murine Typhus IgM and IgG Immunofluorescence Assay: A Systematic Review.The American journal of tropical medicine and hygiene · 2020Pooled it
- Q fever is an old and neglected zoonotic disease in Kenya: a systematic review.BMC public health · 2016Pooled it
- Epidemiology of Coxiella burnetii infection in Africa: a OneHealth systematic review.PLoS neglected tropical diseases · 2014Pooled it
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- Systematic review ofOne health (Amsterdam, Netherlands) · 2026Review
- Seroprevalence of Q fever among humans and animals in East Africa: a systematic review and meta-analysis.One health outlook · 2026Review
- Antibodies to Tick Salivary Antigens AV422 and Calreticulin in Patients With Spotted Fever Group Rickettsioses and Other Febrile Illnesses in Northern Tanzania.The Journal of infectious diseases · 2026Article
- Knowledge, Attitude and Practices Regarding Tick-Borne Diseases Among Healthcare Workers in Two Hospitals in Kilimanjaro, Tanzania: A Cross-Sectional Study.Journal of parasitology research · 2026Article
- Derivation and Internal Validation of a Clinical Prediction Model for Diagnosis of Spotted Fever Group Rickettsioses in Northern Tanzania.Open forum infectious diseases · 2025Article
- Risk Factors for Spotted Fever Group Rickettsioses in Kilimanjaro Region, Tanzania.Open forum infectious diseases · 2024Article
- Metagenomic Detection of Bacterial Zoonotic Pathogens among Febrile Patients, Tanzania, 2007-2009Emerging infectious diseases · 2024Article
- Prevalence and risk factors for Q fever, spotted fever group rickettsioses, and typhus group rickettsioses in a pastoralist community of northern Tanzania, 2016-2017.Tropical medicine & international health : TM & IH · 2024Article
- Aetiology of non-malaria acute febrile illness fever in children in rural Guinea-Bissau: a prospective cross-sectional investigation.Frontiers in epidemiology · 2024Article
- Aetiologies of bacterial tick-borne febrile illnesses in humans in Africa: diagnostic limitations and the need for improvement.Frontiers in medicine · 2024Review
- Wide distribution of Mediterranean and African spotted fever agents and the first identification of Israeli spotted fever agent in ticks in Uganda.PLoS neglected tropical diseases · 2023Article
- Seroprevalence and Risk Factors for Q fever (Veterinary sciences · 2022Article
- Antibody Prevalence and Risk Factors Associated withPathogens (Basel, Switzerland) · 2022Article
- Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania.Scientific reports · 2022Article
23 more citing papers are in PubMed but not listed here.
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14 authors.
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Abstract
backgroundThe importance of Q fever, spotted fever group rickettsiosis (SFGR), and typhus group rickettsiosis (TGR) as causes of febrile illness in sub-Saharan Africa is unknown; the putative role of Q fever as a human immunodeficiency virus (HIV) coinfection is unclear.
methodsWe identified febrile inpatients in Moshi, Tanzania, from September 2007 through August 2008 and collected acute- and convalescent-phase serum samples. A ≥4-fold increase in immunoglobulin (Ig) G immunfluorescence assay (IFA) titer to Coxiella burnetii phase II antigen defined acute Q fever. A ≥4-fold increase in IgG IFA titer to Rickettsia conorii or Rickettsia typhi antigen defined SFGR and TGR, respectively.
resultsAmong 870 patients, 483 (55.5%) were tested for acute Q fever, and 450 (51.7%) were tested for acute SFGR and TGR. Results suggested acute Q fever in 24 (5.0%) patients and SFGR and TGR in 36 (8.0%) and 2 (0.5%) patients, respectively. Acute Q fever was associated with hepato- or splenomegaly (odds ratio [OR], 3.1; P = .028), anemia (OR, 3.0; P = .009), leukopenia (OR, 3.9; P = .013), jaundice (OR, 7.1; P = .007), and onset during the dry season (OR, 2.7; P = .021). HIV infection was not associated with acute Q fever (OR, 1.7; P = .231). Acute SFGR was associated with leukopenia (OR, 4.1; P = .003) and with evidence of other zoonoses (OR, 2.2; P = .045).
conclusionsDespite being common causes of febrile illness in northern Tanzania, Q fever and SFGR are not diagnosed or managed with targeted antimicrobials. C. burnetii does not appear to be an HIV-associated co-infection.
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