Trial reportArchives of pediatrics & adolescent medicine2011
A randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure.
Trial report in Archives of pediatrics & adolescent medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 86 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 5 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Social Risk Interventions and Health Care Utilization for Pediatric Asthma: A Systematic Review and Meta-analysis.JAMA pediatrics · 2022Pooled it
- Impact of non-drug therapies on asthma control: A systematic review of the literature.The European journal of general practice · 2019Pooled it
- Family and carer smoking control programmes for reducing children's exposure to environmental tobacco smoke.The Cochrane database of systematic reviews · 2018Pooled it
- Effectiveness of Interventions to Reduce Tobacco Smoke Pollution in Homes: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2015Pooled it
- Effectiveness of Caregiver Interventions to Reduce Household Secondhand Smoke Exposure on Pediatric Asthma Outcomes: A Systematic Review.Pediatric allergy, immunology, and pulmonologyPooled it
- AIRWEIGHS: A Randomized Controlled Trial of Air Cleaners in Normal Weight and Overweight/Obese Children With Asthma.The journal of allergy and clinical immunology. In practice · 2025Trial
- Principal stratification analysis to determine health benefit of indoor air pollution reduction in a randomized environmental intervention in COPD: Results from the CLEAN AIR study.The Science of the total environment · 2023Trial
- Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Trial
- Patterns and predictors of air purifier adherence in children with asthma living in low-income, urban households.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Trial
- Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: A real-world study.Indoor air · 2022Trial
- Randomized Clinical Trial of Air Cleaners to Improve Indoor Air Quality and Chronic Obstructive Pulmonary Disease Health: Results of the CLEAN AIR Study.American journal of respiratory and critical care medicine · 2022Trial
- Reductions in particulate matter concentrations resulting from air filtration: A randomized sham-controlled crossover study.Indoor air · 2022Trial
- Randomized trial of a portable HEPA air cleaner intervention to reduce asthma morbidity among Latino children in an agricultural community.Environmental health : a global access science source · 2022Trial
- Trial
- Randomised pilot trial of cash incentives for reducing paediatric asthmatic tobacco smoke exposures from maternal caregivers and members of their social network.Archives of disease in childhood · 2021Trial
- Effectiveness of portable HEPA air cleaners on reducing indoor PMIndoor air · 2021Trial
- Effects of Air Purifiers on Patients with Allergic Rhinitis: a Multicenter, Randomized, Double-Blind, and Placebo-Controlled Study.Yonsei medical journal · 2020Trial
- Effects of the Use of Air Purifier on Indoor Environment and Respiratory System among Healthy Adults.International journal of environmental research and public health · 2020Trial
- HEPA filtration improves asthma control in children exposed to traffic-related airborne particles.Indoor air · 2020Trial
- Parental Depression is Prospectively Associated With Lower Smoking Cessation Rates and Poor Child Asthma Outcomes.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Trial
26 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo test an air cleaner and health coach intervention to reduce secondhand smoke exposure compared with air cleaners alone or no air cleaners in reducing particulate matter (PM), air nicotine, and urine cotinine concentrations and increasing symptom-free days in children with asthma residing with a smoker.
designRandomized controlled trial, with randomization embedded in study database. SETTINGS: The Johns Hopkins Hospital Children's Center and homes of children.
participantsChildren with asthma, residing with a smoker, randomly assigned to interventions consisting of air cleaners only (n = 41), air cleaners plus a health coach (n = 41), or delayed air cleaner (control) (n = 44).
main outcome measuresChanges in PM, air nicotine, and urine cotinine concentrations and symptom-free days during the 6-month study.
resultsThe overall follow-up rate was high (91.3%). Changes in mean fine and coarse PM (PM(2.5) and PM(2.5-10)) concentrations (baseline to 6 months) were significantly lower in both air cleaner groups compared with the control group (mean differences for PM(2.5) concentrations: control, 3.5 μg/m(3); air cleaner only, -19.9 μg/m(3); and air cleaner plus health coach, -16.1 μg/m(3); P = .003; and PM(2.5-10) concentrations: control, 2.4 μg/m(3); air cleaner only, -8.7 μg/m(3); and air cleaner plus health coach, -10.6 μg/m(3); P = .02). No differences were noted in air nicotine or urine cotinine concentrations. The health coach provided no additional reduction in PM concentrations. Symptom-free days were significantly increased [corrected] in both air cleaner groups compared with the control group (P = .03).
conclusionAlthough the use of air cleaners can result in a significant reduction in indoor PM concentrations and a significant increase in symptom-free days, it is not enough to prevent exposure to secondhand smoke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.