ArticleDiabetes2011
Therapeutic impact of leptin on diabetes, diabetic complications, and longevity in insulin-deficient diabetic mice.
Article in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Therapeutic mechanisms of mulberry leaves in type 2 diabetes based on metabolomics.Frontiers in pharmacology · 2022Article
- Diabetic mice have retinal and choroidal blood flow deficits and electroretinogram deficits with impaired responses to hypercapnia.PloS one · 2021Article
- Article
- Podocyte Density and Albuminuria in Aging Diabetic Ins2± Mice with or Without Adenosine A1 Receptor Signaling.International journal of nephrology and renovascular disease · 2020Article
- Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Translational science: Newly emerging science in biology and medicine - Lessons from translational research on the natriuretic peptide family and leptin.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019Review
- TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress.Aging cell · 2018Article
- Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.Annals of the New York Academy of Sciences · 2018Review
- Metabolic pressure and the breach of immunological self-tolerance.Nature immunology · 2017Article
- Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system.PloS one · 2017Article
- Does honey have any salutary effect against streptozotocin - induced diabetes in rats?Journal of diabetes and metabolic disorders · 2017Article
- Inner Retinal Oxygen Delivery, Metabolism, and Extraction Fraction in Ins2Akita Diabetic Mice.Investigative ophthalmology & visual science · 2016Article
- Article
- The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy.Molecular metabolism · 2016Article
- Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.Scientific reports · 2016Article
- Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?Clinical diabetes and endocrinology · 2016Article
- Article
- Insulin-independent reversal of type 1 diabetes in nonobese diabetic mice with brown adipose tissue transplant.American journal of physiology. Endocrinology and metabolism · 2015Article
- Dissecting Long-Term Glucose Metabolism Identifies New Susceptibility Period for Metabolic Dysfunction in Aged Mice.PloS one · 2015Article
- Benefits of healthy adipose tissue in the treatment of diabetes.World journal of diabetes · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the current study was to evaluate the long-term effects of leptin on glucose metabolism, diabetes complications, and life span in an insulin-dependent diabetes model, the Akita mouse. RESEARCH DESIGN AND
methodsWe cross-mated Akita mice with leptin-expressing transgenic (LepTg) mice to produce Akita mice with physiological hyperleptinemia (LepTg:Akita). Metabolic parameters were monitored for 10 months. Pair-fed studies and glucose and insulin tolerance tests were performed. The pancreata and kidneys were analyzed histologically. The plasma levels and pancreatic contents of insulin and glucagon, the plasma levels of lipids and a marker of oxidative stress, and urinary albumin excretion were measured. Survival rates were calculated.
resultsAkita mice began to exhibit severe hyperglycemia and hyperphagia as early as weaning. LepTg:Akita mice exhibited normoglycemia after an extended fast even at 10 months of age. The 6-h fasting blood glucose levels in LepTg:Akita mice remained about half the level of Akita mice throughout the study. Food intake in LepTg:Akita mice was suppressed to a level comparable to that in WT mice, but pair feeding did not affect blood glucose levels in Akita mice. LepTg:Akita mice maintained insulin hypersensitivity and displayed better glucose tolerance than did Akita mice throughout the follow-up. LepTg:Akita mice had normal levels of plasma glucagon, a marker of oxidative stress, and urinary albumin excretion rates. All of the LepTg:Akita mice survived for >12 months, the median mortality time of Akita mice.
conclusionsThese results indicate that leptin is therapeutically useful in the long-term treatment of insulin-deficient diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.