ArticleEnvironmental health perspectives2011
Permanent oviduct posteriorization after neonatal exposure to the phytoestrogen genistein.
Article in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.Epigenetics · 2023Article
- Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling.PLoS biology · 2023Article
- Development of adverse outcome pathways relevant for the identification of substances having endocrine disruption properties Uterine adenocarcinoma as adverse outcome.EFSA journal. European Food Safety Authority · 2023Article
- Soy-Based Infant Formula Feeding and Uterine Fibroid Development in a Prospective Ultrasound Study of Black/African-American Women.Environmental health perspectives · 2023Article
- Upregulation of the oestrogen target gene SIX1 is associated with higher growth speed and decreased survival in HCV-positive women with hepatocellular carcinoma.Oncology letters · 2022Article
- Developmental exposure to phytoestrogens found in soy: New findings and clinical implications.Biochemical pharmacology · 2022Review
- Peri- and Postpubertal Estrogen Exposures of Female Mice Optimize Uterine Responses Later in Life.Endocrinology · 2020Article
- Uterine Patterning, Endometrial Gland Development, and Implantation Failure in Mice Exposed Neonatally to Genistein.Environmental health perspectives · 2020Article
- SIX1 Regulates Aberrant Endometrial Epithelial Cell Differentiation and Cancer Latency Following Developmental Estrogenic Chemical Exposure.Molecular cancer research : MCR · 2019Article
- Endocrine Disruption and Reproductive Pathology.Toxicologic pathology · 2019Article
- Neonatal genistein exposure disrupts ovarian and uterine development in the mouse by inhibiting cellular proliferation.The Journal of reproduction and development · 2019Article
- Prenatal Bisphenol A Exposure Alters Epithelial Cell Composition in the Rhesus Macaque Fetal Oviduct.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Soy-based infant formula feeding and menstrual pain in a cohort of women aged 23-35 years.Human reproduction (Oxford, England) · 2019Article
- Differentiation Patterns of Uterine Carcinomas and Precursor Lesions Induced by Neonatal Estrogen Exposure in Mice.Toxicologic pathology · 2018Article
- Widespread enhancer activation via ERα mediates estrogen response in vivo during uterine development.Nucleic acids research · 2018Article
- Neonatal Genistein Exposure and Glucocorticoid Signaling in the Adult Mouse Uterus.Environmental health perspectives · 2018Article
- Linking the Epigenome with Exposure Effects and Susceptibility: The Epigenetic Seed and Soil Model.Toxicological sciences : an official journal of the Society of Toxicology · 2017Review
- SIX1 Oncoprotein as a Biomarker in a Model of Hormonal Carcinogenesis and in Human Endometrial Cancer.Molecular cancer research : MCR · 2016Article
- Timing and recovery of postweaning exposure to diethylstilbestrol on early pregnancy in CD-1 mice.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Bisphenol A exposure alters developmental gene expression in the fetal rhesus macaque uterus.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPreimplantation embryo loss during oviduct transit has been observed in adult mice after a 5-day neonatal exposure to the phytoestrogen genistein (Gen; 50 mg/kg/day).
objectiveWe investigated the mechanisms underlying the contribution of the oviduct to infertility.
methodsFemale mice were treated on postnatal days 1-5 with corn oil or Gen (50 mg/kg/day). We compared morphology, gene expression, and protein expression in different regions of the reproductive tracts of Gen-treated mice with those of control littermates at several time points.
resultsNeonatal Gen treatment resulted in substantial changes in expression of genes that modulate neonatal oviduct morphogenesis, including Hoxa (homeobox A cluster), Wnt (wingless-related MMTV integration site), and hedgehog signaling genes. An estrogen receptor antagonist blocked these effects, indicating that they were induced by the estrogenic activity of Gen. Oviducts of adults treated neonatally with Gen had abnormal morphology and were stably "posteriorized," as indicated by altered Hoxa gene patterning during the time of treatment and dramatic, permanent up-regulation of homeobox genes (e.g., Pitx1, Six1) normally expressed only in the cervix and vagina.
conclusionsNeonatal exposure to estrogenic environmental chemicals permanently disrupts oviduct morphogenesis and adult gene expression patterns, and these changes likely contribute to the infertility phenotype.
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