ArticleVirology2011
Maturation of dengue virus nonstructural protein 4B in monocytes enhances production of dengue hemorrhagic fever-associated chemokines and cytokines.
Article in Virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Membrane Retention of West Nile Virus NS5 Depends on NS1 or NS3 for Enzymatic Activity.Viruses · 2024Article
- Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization.ACS infectious diseases · 2024Article
- Immune-Mediated Pathogenesis in Dengue Virus Infection.Viruses · 2022Review
- Alpha-mangostin inhibits viral replication and suppresses nuclear factor kappa B (NF-κB)-mediated inflammation in dengue virus infection.Scientific reports · 2022Article
- Selective Reactivity of Anti-Japanese Encephalitis Virus NS4B Antibody Towards Different Flaviviruses.Viruses · 2020Article
- Secretion of Galectin-9 as a DAMP during Dengue Virus Infection in THP-1 Cells.International journal of molecular sciences · 2017Article
- Review
- The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.PLoS pathogens · 2016Article
- Production of a Recombinant Dengue Virus 2 NS5 Protein and Potential Use as a Vaccine Antigen.Clinical and vaccine immunology : CVI · 2016Article
- Bioinformatic analysis reveals the expression of unique transcriptomic signatures in Zika virus infected human neural stem cells.Cell & bioscience · 2016Article
- Functional Analysis of West Nile Virus Proteins in Human Cells.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4B.PloS one · 2014Article
- Potential evidence for biotype-specific chemokine profile following BVDV infection of bovine macrophages.Veterinary immunology and immunopathology · 2012Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
High levels of viremia and chemokines and cytokines underlie the progression of severe dengue disease. Dengue virus (DENV) preferentially infects peripheral blood monocytes, which secrete elevated levels of immunomediators in patients with severe disease. Further, DENV nonstructural proteins (NS) are capable of modifying intracellular signaling, including interferon inhibition. We demonstrate that peak secretions of immunomediators such as IL-6, IL-8, IP-10, TNFα or IFNγ in DENV-infected monocytes correlate with maximum virus production and NS4B and NS5 are primarily responsible for the induction of immunomediators. Furthermore, we demonstrate that sequential NS4AB processing initiated by the viral protease NS2B3(pro) and via the intermediate 2KNS4B significantly enhances immunomediator induction. While the 2K-signal peptide is not essential for immunomediator induction, it plays a synergistic role with NS4B. These data suggest that NS4B maturation is important during innate immune signaling in DENV-infected monocytes. Given similar NS4B topologies and polyprotein processing across flaviviruses, NS4B may be an attractive target for developing Flavivirus-wide therapeutic interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.