Trial reportParasitology2011
Treatment with anthelminthics during pregnancy: what gains and what risks for the mother and child?
Trial report in Parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Effects of deworming on child and maternal health: a literature review and meta-analysis.BMC public health · 2017Pooled it
- Complexities and Perplexities: A Critical Appraisal of the Evidence for Soil-Transmitted Helminth Infection-Related Morbidity.PLoS neglected tropical diseases · 2016Pooled it
- Praziquantel for the treatment of schistosomiasis during human pregnancy.Bulletin of the World Health Organization · 2018Trial
- Therapeutic Management of Schistosomiasis in Pregnancy: A Comprehensive Review of Praziquantel Safety and Clinical Outcomes.Biomedicines · 2026Review
- Anthelmintic medication with focus on first-trimester exposure: an evaluation of pregnancy outcomes based on the Embryotox cohort.Scientific reports · 2026Article
- Management ofIDCases · 2025Article
- Impact of schistosomiasis infection on maternal and neonatal outcomes in pregnancy: a prospective cohort study in Nigeria.BMC pregnancy and childbirth · 2024Article
- Article
- Mapping the quality of prenatal and postnatal care and demographic differences on child mortality in 26 low to middle-income countries.World journal of pediatrics : WJP · 2023Article
- Severe adverse reaction induced by albendazole and praziquantel for cystic echinococcosis.IDCases · 2023Article
- Intestinal Parasitic Infections, Treatment and Associated Factors among Pregnant Women in Sao Tome and Principe: A Cross-Sectional Study.Journal of tropical medicine · 2022Article
- A Review on Strongyloidiasis in Pregnant Women.Research and reports in tropical medicine · 2021Review
- Regulatory T-cells in helminth infection: induction, function and therapeutic potential.Immunology · 2020Review
- Variation in KSHV prevalence between geographically proximate locations in Uganda.Infectious agents and cancer · 2020Article
- Prevalence of helminthic infections and determinant factors among pregnant women in Mecha district, Northwest Ethiopia: a cross sectional study.BMC infectious diseases · 2018Article
- A New Look at Care in Pregnancy: Simple, Effective Interventions for Neglected Populations.PloS one · 2016Review
- Helminth infection during pregnancy: insights from evolutionary ecology.International journal of women's health · 2016Review
- Impact of helminth infection during pregnancy on cognitive and motor functions of one-year-old children.PLoS neglected tropical diseases · 2015Article
- Maternal schistosomiasis: a growing concern in sub-Saharan Africa.Pathogens and global health · 2014Review
- The association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal Kenya.PLoS neglected tropical diseases · 2014Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
In 1994 and 2002, respectively, the World Health Organisation proposed that treatment for hookworm and schistosomiasis could be provided during pregnancy. It was hoped that this might have benefits for maternal anaemia, fetal growth and perinatal mortality; a beneficial effect on the infant response to immunisation was also hypothesised. Three trials have now been conducted. Two have examined the effects of benzimidazoles; one (the Entebbe Mother and Baby Study) the effects of albendazole and praziquantel. All three were conducted in settings of high prevalence but low intensity helminth infection. Results suggest that, in such settings and given adequate provision of haematinics, the benefit of routine anthelminthics during pregnancy for maternal anaemia may be small; none of the other expected benefits has yet been demonstrated. The Entebbe Mother and Baby Study found a significant adverse effect of albendazole on the incidence of infantile eczema in the whole study population, and of praziquantel on the incidence of eczema among infants of mothers with Schistosoma mansoni. Further studies are required in settings that differ in helminth species and infection intensities. Further research is required to determine whether increased rates of infantile eczema translate to long-term susceptibility to allergy, and to explore the underlying mechanisms of these effects. The risks and benefits of routine anthelminthic treatment in antenatal clinics may need to be reconsidered.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.