ArticleEnvironmental health : a global access science source2011
Personal endotoxin exposure in a panel study of school children with asthma.
Article in Environmental health : a global access science source, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Human personal air pollution clouds in a naturally ventilated office during the COVID-19 pandemic.Building and environment · 2023Article
- Correlation between levels of airborne endotoxin and heavy metals in subway environments in South Korea.Scientific reports · 2021Article
- Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program.Journal of exposure science & environmental epidemiology · 2020Review
- Predictors and respiratory depositions of airborne endotoxin in homes using biomass fuels and LPG gas for cooking.Journal of exposure science & environmental epidemiology · 2017Article
- Introducing an environmental assessment and intervention program in inner-city schools.The Journal of allergy and clinical immunology · 2014Review
- Allergen ligands in the initiation of allergic sensitization.Current allergy and asthma reports · 2014Article
- Article
- Time for new methods for avoidance of house dust mite and other allergens.Current allergy and asthma reports · 2012Article
- Recent advances in the epidemiologic investigation of risk factors for asthma: a review of the 2011 literature.Current allergy and asthma reports · 2012Review
- Airway inflammation and oxidative potential of air pollutant particles in a pediatric asthma panel.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEndotoxin exposure has been associated with asthma exacerbations and increased asthma prevalence. However, there is little data regarding personal exposure to endotoxin in children at risk, or the relation of personal endotoxin exposure to residential or ambient airborne endotoxin. The relation between personal endotoxin and personal air pollution exposures is also unknown.
methodsWe characterized personal endotoxin exposures in 45 school children with asthma ages 9-18 years using 376 repeated measurements from a PM2.5 active personal exposure monitor. We also assayed endotoxin in PM2.5 samples collected from ambient regional sites (N = 97 days) and from a subset of 12 indoor and outdoor subject home sites (N = 109 and 111 days, respectively) in Riverside and Whittier, California. Endotoxin was measured using the Limulus Amoebocyte Lysate kinetic chromogenic assay. At the same time, we measured personal, home and ambient exposure to PM2.5 mass, elemental carbon (EC), and organic carbon (OC). To assess exposure relations we used both rank correlations and mixed linear regression models, adjusted for personal temperature and relative humidity.
resultsWe found small positive correlations of personal endotoxin with personal PM2.5 EC and OC, but not personal PM2.5 mass or stationary site air pollutant measurements. Outdoor home, indoor home and ambient endotoxin were moderately to strongly correlated with each other. However, in mixed models, personal endotoxin was not associated with indoor home or outdoor home endotoxin, but was associated with ambient endotoxin. Dog and cat ownership were significantly associated with increased personal but not indoor endotoxin.
conclusionsDaily fixed site measurements of endotoxin in the home environment may not predict daily personal exposure, although a larger sample size may be needed to assess this. This conclusion is relevant to short-term exposures involved in the acute exacerbation of asthma.
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