ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2012
Inhibin A enhances bone formation during distraction osteogenesis.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Rho-associated coiled-coil-containing protein kinase inhibitor Y-27632 promotes distraction osteogenesis healing by activating both osteoblasts and osteoclasts.Nagoya journal of medical science · 2025Article
- Activated FGFR3 suppresses bone regeneration and bone mineralization in an ovariectomized mouse model.BMC musculoskeletal disorders · 2023Article
- Diabetes mellitus impairs bone regeneration and biomechanics.Journal of orthopaedic surgery and research · 2023Article
- High-fat diet causes undesirable bone regeneration by altering the bone marrow environment in rats.Frontiers in endocrinology · 2023Article
- Inhibin Inactivation in Female Mice Leads to Elevated FSH Levels, Ovarian Overstimulation, and Pregnancy Loss.Endocrinology · 2022Article
- Hypoxia During the Consolidation Phase of Distraction Osteogenesis Promotes Bone Regeneration.Frontiers in physiology · 2022Article
- Cyclic Distraction-Compression Dynamization Technique Enhances the Bone Formation During Distraction Osteogenesis.Frontiers in bioengineering and biotechnology · 2021Article
- Inhibition of GDF8 (Myostatin) accelerates bone regeneration in diabetes mellitus type 2.Scientific reports · 2017Article
- Nutlin-3 treatment spares cisplatin-induced inhibition of bone healing while maintaining osteosarcoma toxicity.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis.Arthritis research & therapy · 2015Article
- Cisplatin inhibits bone healing during distraction osteogenesis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2014Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Given the aging population and the increased incidence of fracture in the elderly population, the need exists for agents that can enhance bone healing, particularly in situations of delayed fracture healing and/or non-union. Our previous studies demonstrated that overexpression of the gonadal peptide, human inhibin A (hInhA), in transgenic mice enhances bone formation and strength via increased osteoblast activity. We tested the hypothesis that hInhA can also exert anabolic effects in a murine model of distraction osteogenesis (DO), using both transgenic hInhA overexpression and administration of normal physiological levels of hInhA in adult male Swiss-Webster mice. Tibial osteotomies and external ring fixation were performed, followed by a 3-day latency period, 14-day distraction, and sacrifice on day 18. Supraphysiological levels of hInhA in transgenic mice, but not normal physiological levels of hInhA, significantly increased endosteal bone formation and mineralized bone area in the distraction gap, as determined by radiographic and µCT analysis. Significantly, increased PCNA and osteocalcin expression in the primary matrix front suggested that hInhA increased osteoblast proliferation. This mechanism is consistent with the effects of other agents and pathologies that modulate bone formation during DO, and demonstrates the potential of hInhA to enhance bone repair and regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.