ArticleAnnals of biomedical engineering2011
Ensuring congruency in multiscale modeling: towards linking agent based and continuum biomechanical models of arterial adaptation.
Article in Annals of biomedical engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Multiscale Kinematic Growth Coupled With Mechanosensitive Systems Biology in Open-Source Software.Journal of biomechanical engineering · 2025Article
- Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling.Journal of the Royal Society, Interface · 2025Review
- Multiscale computational model predicts how environmental changes and treatments affect microvascular remodeling in fibrotic disease.PNAS nexus · 2025Article
- A Systems Approach to Biomechanics, Mechanobiology, and Biotransport.Journal of biomechanical engineering · 2024Article
- Multiscale computational model predicts how environmental changes and drug treatments affect microvascular remodeling in fibrotic disease.bioRxiv : the preprint server for biology · 2024Article
- Bioengineering and the cervix: The past, current, and future for addressing preterm birth.Current research in physiology · 2023Review
- Biomechanical phenotyping of minuscule soft tissues: An example in the rodent tricuspid valve.Extreme Mechanics Letters · 2022Article
- Constrained Mixture Models of Soft Tissue Growth and Remodeling - Twenty Years After.Journal Of Elasticity · 2021Article
- Article
- Mechanobiological model of arterial growth and remodeling.Biomechanics and modeling in mechanobiology · 2018Article
- Identifying mechanisms driving formation of granuloma-associated fibrosis during Mycobacterium tuberculosis infection.Journal of theoretical biology · 2017Article
- An engineering design approach to systems biology.Integrative biology : quantitative biosciences from nano to macro · 2017Review
- Bio-Chemo-Mechanical Models of Vascular Mechanics.Annals of biomedical engineering · 2015Review
- Agent-based computational model investigates muscle-specific responses to disuse-induced atrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Applications of computational models to better understand microvascular remodelling: a focus on biomechanical integration across scales.Interface focus · 2015Review
- Models of signalling networks - what cell biologists can gain from them and give to them.Journal of cell science · 2013Review
- Article
- Multiscale computational models of complex biological systems.Annual review of biomedical engineering · 2013Review
- Multiscale models of cell signaling.Annals of biomedical engineering · 2012Review
- Extracellular matrix and the mechanics of large artery development.Biomechanics and modeling in mechanobiology · 2012Article
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Authors and funding
4 authors.
Funding
Abstract
There is a need to develop multiscale models of vascular adaptations to understand tissue-level manifestations of cellular level mechanisms. Continuum-based biomechanical models are well suited for relating blood pressures and flows to stress-mediated changes in geometry and properties, but less so for describing underlying mechanobiological processes. Discrete stochastic agent-based models are well suited for representing biological processes at a cellular level, but not for describing tissue-level mechanical changes. We present here a conceptually new approach to facilitate the coupling of continuum and agent-based models. Because of ubiquitous limitations in both the tissue- and cell-level data from which one derives constitutive relations for continuum models and rule-sets for agent-based models, we suggest that model verification should enforce congruency across scales. That is, multiscale model parameters initially determined from data sets representing different scales should be refined, when possible, to ensure that common outputs are consistent. Potential advantages of this approach are illustrated by comparing simulated aortic responses to a sustained increase in blood pressure predicted by continuum and agent-based models both before and after instituting a genetic algorithm to refine 16 objectively bounded model parameters. We show that congruency-based parameter refinement not only yielded increased consistency across scales, it also yielded predictions that are closer to in vivo observations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.