ArticleOrthopedic reviews2010
Cell therapy in bone healing disorders.
Article in Orthopedic reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of Stem Cell Therapies for Pain in Diabetic Neuropathy, Osteoarthritis, and Spinal Cord Injuries.Current pain and headache reports · 2025Pooled it
- Bone Marrow Aspirate Concentrate versus Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells for Combined Cartilage Regeneration Procedure in Patients Undergoing High Tibial Osteotomy: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Autologous mesenchymal stromal cells embedded in tricalcium phosphate for posterolateral spinal fusion: results of a prospective phase I/II clinical trial with long-term follow-up.Stem cell research & therapy · 2019Trial
- The Effect of Amniotic Tissue on Spinal Interventions: A Systematic Review.International journal of spine surgery · 2023Article
- Does Needle Design Affect the Regenerative Potential of Bone Marrow Aspirate? An In Vitro Study.Life (Basel, Switzerland) · 2021Article
- Article
- Evaluation of the Consistency and Composition of Commercially Available Bone Marrow Aspirate Concentrate Systems.Orthopaedic journal of sports medicine · 2020Article
- Osteogenic ability of rat bone marrow concentrate is at least as efficacious as mesenchymal stem cells in vitro.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Substantial Overview on Mesenchymal Stem Cell Biological and Physical Properties as an Opportunity in Translational Medicine.International journal of molecular sciences · 2019Review
- Cellular therapy: A promising tool in the future of colorectal surgery.World journal of gastroenterology · 2019Review
- Innovative Biomaterials for Bone Regrowth.International journal of molecular sciences · 2019Review
- Autologous cell-based therapy for treatment of large bone defects: from bench to bedside.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Review
- Article
- The Holy Grail of Orthopedic Surgery: Mesenchymal Stem Cells-Their Current Uses and Potential Applications.Stem cells international · 2017Review
- Sartorius muscle pedicle iliac bone graft for the treatment of avascular necrosis of femur head.Journal of hip preservation surgery · 2016Article
- Mesenchymal stem cells that located in the electromagnetic fields improves rat model of Parkinson's disease.Iranian journal of basic medical sciences · 2016Article
- Non-Hematopoietic Essential Functions of Bone Marrow Cells: A Review of Scientific and Clinical Literature and Rationale for Treating Bone Defects.Orthopedic reviews · 2015Review
- Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair.Advanced drug delivery reviews · 2015Review
- Hard tissue regeneration using bone substitutes: an update on innovations in materials.The Korean journal of internal medicine · 2015Review
- The effect of bone marrow concentrate and hyperbaric oxygen therapy on bone repair.Journal of materials science. Materials in medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to osteosynthetic stabilizing techniques and autologous bone transplantations, so-called orthobiologics play an increasing role in the treatment of bone healing disorders. Besides the use of various growth factors, more and more new data suggest that cell-based therapies promote local bone regeneration. For ethical and biological reasons, clinical application of progenitor cells on the musculoskeletal system is limited to autologous, postpartum stem cells. Intraoperative one-step treatment with autologous progenitor cells, in particular, delivered promising results in preliminary clinical studies. This article provides an overview of the rationale for, and characteristics of the clinical application of cell-based therapy to treat osseous defects based on a review of existing literature and our own experience with more than 100 patients. Most clinical trials report successful bone regeneration after the application of mixed cell populations from bone marrow. The autologous application of human bone marrow cells which are not expanded ex vivo has medico-legal advantages. However, there is a lack of prospective randomized studies including controls for cell therapy for bone defects. Autologous bone marrow cell therapy seems to be a promising treatment option which may reduce the amount of bone grafting in future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.