ArticleFrontiers in psychiatry2011
Variations in Maternal Behavior in C57BL/6J Mice: Behavioral Comparisons between Adult Offspring of High and Low Pup-Licking Mothers.
Article in Frontiers in psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
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- Early Handling Exerts Anxiolytic Effects and Alters Brain Mitochondrial Dynamics in Adult High Anxiety Mice.Molecular neurobiology · 2024Article
- The role of epigenetic mechanisms in the long-term effects of early-life adversity and mother-infant relationship on physiology and behavior of offspring in laboratory rats and mice.Developmental psychobiology · 2024Review
- Sexually dimorphic oxytocin receptor-expressing (OXTR) neurons in the anteroventral periventricular nucleus (AVPV) in the postpartum female mouse are involved in maternal behavior.Journal of neuroendocrinology · 2023Article
- Prenatal stress unmasks behavioral phenotypes in genetic mouse models of neurodevelopmental disorders.Frontiers in behavioral neuroscience · 2023Review
- Article
- Generation and characterization of Ccdc28b mutant mice links the Bardet-Biedl associated gene with mild social behavioral phenotypes.PLoS genetics · 2022Article
- The Neurobiology of Behavior and Its Applicability for Animal Welfare: A Review.Animals : an open access journal from MDPI · 2022Review
- Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress.Neurobiology of stress · 2022Article
- Interfering With Contextual Fear Memories by Post-reactivation Administration of Propranolol in Mice: A Series of Null Findings.Frontiers in behavioral neuroscience · 2022Article
- Raised without a father: monoparental care effects over development, sexual behavior, sexual reward, and pair bonding in prairie voles.Behavioural brain research · 2021Article
- Behavior Testing in Rodents: Highlighting Potential Confounds Affecting Variability and Reproducibility.Brain sciences · 2021Review
- Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders.Journal of neurodevelopmental disorders · 2021Review
- Microbiota control of maternal behavior regulates early postnatal growth of offspring.Science advances · 2021Article
- Maternal stressors and the developmental origins of neuropsychiatric risk.Frontiers in neuroendocrinology · 2020Review
- Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.Genes, brain, and behavior · 2020Article
- Sham-Chewing in Sows Is Associated With Decreased Fear Responses in Their Offspring.Frontiers in veterinary science · 2019Article
- Cross-Generational Transmission of Early Life Stress Effects on HPA Regulators and Bdnf Are Mediated by Sex, Lineage, and Upbringing.Frontiers in behavioral neuroscience · 2019Article
- Postnatal Light Effects on Pup Stress Axis Development Are Independent of Maternal Behavior.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The amount of maternal licking received by newborn rats affects their adult stress reactivity and maternal behavior. Mouse studies in which litters were cross-fostered between strains that exhibit high vs. low amounts of maternal behavior also suggest that rearing conditions affect adult outcomes. The current study is the first to compare within a single mouse strain (C57BL/6J) behavioral responses between adult animals reared by mothers that exhibited frequencies of pup-licking (PL) at the high end and the low end of the normal distribution within the strain. Maternal behaviors were coded during 10-s intervals every 3 min during five 1-h periods (two light, three dark cycle) on postpartum days 2, 4, 6, and 8 in 36 unrelated C57BL/6J mothers. The distribution of mean frequencies/h for PL, still crouched nursing, hovering over pups, self-grooming, and no contact with pups were determined. Offspring (6-12 weeks of age) from the eight mothers who exhibited the highest mean frequencies of PL and the seven mothers who exhibited the lowest PL frequencies underwent the following tests over three consecutive weeks: (1) elevated plus-maze (EPM) and 1-h open field on three successive days, (2) 3-h open field with an acute stressor (IP saline injection) at the 1-h time point, and (3) acoustic startle and prepulse inhibition. Females reared by low PL mothers exhibited significantly more time in the closed arms of the EPM, less locomotion, center time, and rearing during the first test in the open field, greater reactivity to an acute stressor, and reduced prepulse inhibition, an index of sensorimotor gating. Male offspring from low PL dams had reduced reactivity to an acute stressor, but no other altered performance in the behavioral tests. PL frequencies of C57BL/6J mothers appear to selectively alter behavior outcomes, primarily in female offspring.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.