ArticleFrontiers in behavioral neuroscience2011
The roles of the actin cytoskeleton in fear memory formation.
Article in Frontiers in behavioral neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
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- Effects of berberine hydrochloride on methamphetamine-induced anxiety behaviors and relapse in rats.Iranian journal of basic medical sciences · 2020Article
- The Role of ADF/Cofilin in Synaptic Physiology and Alzheimer's Disease.Frontiers in cell and developmental biology · 2020Review
- Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome.Molecular neurobiology · 2018Article
- SPIN90 Modulates Long-Term Depression and Behavioral Flexibility in the Hippocampus.Frontiers in molecular neuroscience · 2017Article
- Ancient Anxiety Pathways Influence Drosophila Defense Behaviors.Current biology : CB · 2016Article
- Post-training activation of Rac1 in the basolateral amygdala is required for the formation of both short-term and long-term auditory fear memory.Frontiers in molecular neuroscience · 2015Article
- Loss of prion protein leads to age-dependent behavioral abnormalities and changes in cytoskeletal protein expression.Molecular neurobiology · 2014Article
- EphrinA4 mimetic peptide targeted to EphA binding site impairs the formation of long-term fear memory in lateral amygdala.Translational psychiatry · 2014Article
- The synthetic thyroid hormone, levothyroxine, protects cholinergic neurons in the hippocampus of naturally aged mice.Neural regeneration research · 2014Article
- Mechanism based approaches for rescuing and enhancing cognition.Frontiers in neuroscience · 2013Article
- From Drosophila development to adult: clues to Notch function in long-term memory.Frontiers in cellular neuroscience · 2013Article
- Cytoskeletal protein translation and expression in the rat brain are stressor-dependent and region-specific.PloS one · 2013Article
- Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The formation and storage of fear memory is needed to adapt behavior and avoid danger during subsequent fearful events. However, fear memory may also play a significant role in stress and anxiety disorders. When fear becomes disproportionate to that necessary to cope with a given stimulus, or begins to occur in inappropriate situations, a fear or anxiety disorder exists. Thus, the study of cellular and molecular mechanisms underpinning fear memory may shed light on the formation of memory and on anxiety and stress related disorders. Evidence indicates that fear learning leads to changes in neuronal synaptic transmission and morphology in brain areas underlying fear memory formation including the amygdala and hippocampus. The actin cytoskeleton has been shown to participate in these key neuronal processes. Recent findings show that the actin cytoskeleton is needed for fear memory formation and extinction. Moreover, the actin cytoskeleton is involved in synaptic plasticity and in neuronal morphogenesis in brain areas that mediate fear memory. The actin cytoskeleton may therefore mediate between synaptic transmission during fear learning and long-term cellular alterations mandatory for fear memory formation.
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