ArticleFrontiers in systems neuroscience2011
Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact.
Article in Frontiers in systems neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior.Nature communications · 2024Article
- Bayesian Mapping of the Striatal Microcircuit Reveals Robust Asymmetries in the Probabilities and Distances of Connections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Frequency-dependent entrainment of striatal fast-spiking interneurons.Journal of neurophysiology · 2019Article
- Alteration of GABAergic neurotransmission in Huntington's disease.CNS neuroscience & therapeutics · 2018Review
- Differential Alteration in Expression of Striatal GABAFrontiers in molecular neuroscience · 2017Article
- Interplay between periodic stimulation and GABAergic inhibition in striatal network oscillations.PloS one · 2017Article
- A Low-Correlation Resting State of the Striatum during Cortical Avalanches and Its Role in Movement Suppression.PLoS biology · 2016Article
- Npas1+ Pallidal Neurons Target Striatal Projection Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Mutual Control of Cholinergic and Low-Threshold Spike Interneurons in the Striatum.Frontiers in cellular neuroscience · 2016Article
- Optogenetic stimulation reveals distinct modulatory properties of thalamostriatal vs corticostriatal glutamatergic inputs to fast-spiking interneurons.Scientific reports · 2015Article
- Are striatal tyrosine hydroxylase interneurons dopaminergic?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Therapeutic mechanisms of high-frequency stimulation in Parkinson's disease and neural restoration via loop-based reinforcement.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Lateral and feedforward inhibition suppress asynchronous activity in a large, biophysically-detailed computational model of the striatal network.Frontiers in computational neuroscience · 2014Article
- Effect of phase response curve skewness on synchronization of electrically coupled neuronal oscillators.Neural computation · 2013Article
- Evolutionarily conserved differences in pallial and thalamic short-term synaptic plasticity in striatum.The Journal of physiology · 2013Article
- Target selectivity of feedforward inhibition by striatal fast-spiking interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Different correlation patterns of cholinergic and GABAergic interneurons with striatal projection neurons.Frontiers in systems neuroscience · 2013Article
- Signal enhancement in the output stage of the basal ganglia by synaptic short-term plasticity in the direct, indirect, and hyperdirect pathways.Frontiers in computational neuroscience · 2013Article
- Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons.Frontiers in cellular neuroscience · 2013Article
- Functional properties of striatal fast-spiking interneurons.Frontiers in systems neuroscience · 2011Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
In the striatal microcircuit, fast-spiking (FS) interneurons have an important role in mediating inhibition onto neighboring medium spiny (MS) projection neurons. In this study, we combined computational modeling with in vitro and in vivo electrophysiological measurements to investigate FS cells in terms of their discharge properties and their synaptic efficacies onto MS neurons. In vivo firing of striatal FS interneurons is characterized by a high firing variability. It is not known, however, if this variability results from the input that FS cells receive, or if it is promoted by the stuttering spike behavior of these neurons. Both our model and measurements in vitro show that FS neurons that exhibit random stuttering discharge in response to steady depolarization do not show the typical stuttering behavior when they receive fluctuating input. Importantly, our model predicts that electrically coupled FS cells show substantial spike synchronization only when they are in the stuttering regime. Therefore, together with the lack of synchronized firing of striatal FS interneurons that has been reported in vivo, these results suggest that neighboring FS neurons are not in the stuttering regime simultaneously and that in vivo FS firing variability is more likely determined by the input fluctuations. Furthermore, the variability in FS firing is translated to variability in the postsynaptic amplitudes in MS neurons due to the strong synaptic depression of the FS-to-MS synapse. Our results support the idea that these synapses operate over a wide range from strongly depressed to almost fully recovered. The strong inhibitory effects that FS cells can impose on their postsynaptic targets, and the fact that the FS-to-MS synapse model showed substantial depression over extended periods of time might indicate the importance of cooperative effects of multiple presynaptic FS interneurons and the precise orchestration of their activity.
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