ArticleLaboratory investigation; a journal of technical methods and pathology2011
In vivo, label-free, three-dimensional quantitative imaging of kidney microcirculation using Doppler optical coherence tomography.
Article in Laboratory investigation; a journal of technical methods and pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 42 citations in OpenAlex.
- Label-free volumetric imaging of porcine kidney tissue over extended areas using dynamic MHz-OCT.Scientific reports · 2025Article
- In vivo imaging of renal microvasculature in a murine ischemia-reperfusion injury model using optical coherence tomography angiography.Scientific reports · 2023Article
- Fangchinoline alleviates cognitive impairments through enhancing autophagy and mitigating oxidative stress in Alzheimer's disease models.Frontiers in cell and developmental biology · 2023Article
- Peripheral intravenous infusion for children based on computer digital video technology.American journal of translational research · 2023Article
- Optical coherence microangiography of the mouse kidney for diagnosis of circulatory disorders.Biomedical optics express · 2021Article
- Fully automated analysis of OCT imaging of human kidneys for prediction of post-transplant function.Biomedical optics express · 2019Article
- Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease.Journal of biomedical optics · 2017Article
- Monitoring kidney microanatomy changes during ischemia-reperfusion process using texture analysis of OCT images.IEEE photonics journal · 2017Article
- Functional optical coherence tomography: principles and progress.Physics in medicine and biology · 2015Review
- Three dimensional mesoscale analysis of translamellar cross-bridge morphologies in the annulus fibrosus using optical coherence tomography.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- In vivo pump-probe optical coherence tomography imaging in Xenopus laevis.Journal of biophotonics · 2015Article
- Mannitol infusion within 15 min of cross-clamp improves living donor kidney preservation.Transplantation · 2014Article
- Clinical applications of optical coherence tomography in urology.Intravital · 2014Review
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Doppler optical coherence tomography (DOCT) is a functional extension of optical coherence tomography (OCT) and is currently being employed in several clinical arenas to quantify blood flow in vivo. In this study, the objective was to investigate the feasibility of DOCT to image kidney microcirculation, specifically, glomerular blood flow. DOCT is able to capture three-dimensional (3D) data sets consisting of a series of cross-sectional images in real time, which enables label-free and non-destructive quantification of glomerular blood flow. The kidneys of adult, male Munich-Wistar rats were exposed through laparotomy procedure after being anesthetized. Following exposure of the kidney beneath the DOCT microscope, glomerular blood flow was observed. The effects of acute mannitol and angiotensin II infusion were also observed. Glomerular blood flow was quantified for the induced physiological states and compared with baseline measurements. Glomerular volume, cumulative Doppler volume, and Doppler flow range parameters were computed from 3D OCT/DOCT data sets. Glomerular size was determined from OCT, and DOCT readily revealed glomerular blood flow. After infusion of mannitol, a significant increase in blood flow was observed and quantified, and following infusion of angiontensin II, a significant decrease in blood flow was observed and quantified. Also, blood flow histograms were produced to illustrate differences in blood flow rate and blood volume among the induced physiological states. We demonstrated 3D DOCT imaging of rat kidney microcirculation in the glomerulus in vivo. Dynamic changes in blood flow were detected under altered physiological conditions demonstrating the real-time imaging capability of DOCT. This method holds promise to allow non-invasive imaging of kidney blood flow for transplant graft evaluation or monitoring of altered-renal hemodynamics related to disease progression.
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